Map2k6 - mitogen-activated protein kinase kinase 6 Gene

Mus musculus

Also known as MEK6; MKK6; MAPKK6; Prkmk6; SAPKK3; MAPKK 6

Gene ID: 26399 | Gene type: protein coding

About Map2k6

Summary

Enables MAP kinase kinase activity; Phosphatase activator activity; and protein serine/threonine kinase activator activity. Involved in bone development; negative regulation of cold-induced thermogenesis; and osteoblast differentiation. Acts upstream of or within several processes, including MAPK cascade; cardiac muscle contraction; and positive regulation of MAP kinase activity. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Pick's disease; cervical cancer; ovarian carcinoma; progressive supranuclear palsy; and restrictive cardiomyopathy. Orthologous to human MAP2K6 (mitogen-activated protein kinase kinase 6). [provided by Alliance of Genome Resources, Apr 2022]

Map2k6 Products(6)

mRNA	Protein	Name
NM_001356345.1	NP_001343274.1	dual specificity mitogen-activated protein kinase kinase 6 isoform 2
NM_001356346.1	NP_001343275.1	dual specificity mitogen-activated protein kinase kinase 6 isoform 3
NM_001356347.1	NP_001343276.1	dual specificity mitogen-activated protein kinase kinase 6 isoform 3
NM_001356352.1	NP_001343281.1	dual specificity mitogen-activated protein kinase kinase 6 isoform 3
NM_001356353.1	NP_001343282.1	dual specificity mitogen-activated protein kinase kinase 6 isoform 4
NM_011943.3	NP_036073.1	dual specificity mitogen-activated protein kinase kinase 6 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables MAP kinase kinase activity	IMP IMP: Inferred from mutant phenotype	20551513	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12556533	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in MAPK cascade	IMP IMP: Inferred from mutant phenotype	20551513	MGI
acts upstream of or within MAPK cascade	IPI IPI: Inferred from physical interaction	12556533	MGI
involved in bone development	IMP IMP: Inferred from mutant phenotype	20551513	MGI
acts upstream of or within cardiac muscle contraction	IMP IMP: Inferred from mutant phenotype	11593045	MGI
involved in negative regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	29021624	MGI
involved in osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	20551513	MGI
acts upstream of or within positive regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	14744933	MGI
acts upstream of or within positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	15767678	MGI
acts upstream of or within positive regulation of MAPK cascade	IGI IGI: Inferred from genetic interaction	15767678	MGI
acts upstream of or within positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	11593045	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	12213961	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dual specificity mitogen-activated protein kinase kinase 6

MAP kinase kinase 6	MAPK/ERK kinase 6
protein kinase, mitogen activated, kinase 6

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08044	MAP2K6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17782	Map2k6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24249	Map2k6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Map2k6	NCBI	NCBI:5608

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