Mfrp - membrane frizzled-related protein Gene

Mus musculus

Also known as rd6

Gene ID: 259172 | Gene type: protein coding

About Mfrp

Summary

The protein encoded by this gene contains a region with similarity to the cysteine-rich domain (CRD) of Frizzled, a gene originally found in Drosophila that controls tissue polarity. This protein functions in eye development, where it is necessary for the maintenance of photoreceptor outer segments. Mutations in this gene cause retinal degeneration 6 in mice, which gives rise to a mouse model for human retinitis punctata albescens. Bicistronic transcripts composed of the coding sequences for this gene (Mfrp) and the C1q and tumor necrosis factor related protein 5 gene (C1qtnf5) have been identified, and the resulting products can interact with each Other. Co-transcription of C1qtnf5 and Mfrp has been observed in both human and mouse. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

Mfrp Products(2)

mRNA	Protein	Name
NM_001190314.1	NP_001177243.1	membrane frizzled-related protein isoform 2
NM_147126.3	NP_667337.1	membrane frizzled-related protein isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16600989	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within eye photoreceptor cell development	IMP IMP: Inferred from mutant phenotype	21052544	MGI
acts upstream of or within retina development in camera-type eye	IMP IMP: Inferred from mutant phenotype	21052544	MGI
acts upstream of or within visual perception	IMP IMP: Inferred from mutant phenotype	12140190	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

membrane frizzled-related protein

membrane-type frizzled-related protein

Mfrp Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Mfrp	Q8K480	C1qtnf5	Mus musculus	Q8K479	Confocal	16600989
Intra	Mfrp	Q8K480	C1qtnf5	Mus musculus	Q8K479	Anti Tag CoIP	16600989
Intra	Mfrp	Q8K480	C1qtnf5	Mus musculus	Q8K479	Confocal	17122143
Intra	Mfrp	Q8K480	C1qtnf5	Mus musculus	Q8K479	Anti Bait CoIP	17122143

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08386	MFRP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22233	Mfrp Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mfrp	NCBI	NCBI:83552

Name
Email *

	Sorry, but the email address you supplied was invalid.