MYH9 - Myh9 myosin, heavy chain 9 Gene

Rattus norvegicus

Also known as NMIIA; Myh9l1

Gene ID: 25745 | Gene type: protein coding

About MYH9

Summary

Enables several functions, including G-protein alpha-subunit binding activity; follicle-stimulating hormone receptor binding activity; and scaffold protein binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; actin Cytoskeleton organization; and positive regulation of cell communication. Located in several cellular components, including actin filament; brush border; and lateral plasma membrane. Part of protein-containing complex. Colocalizes with endosome and phagocytic vesicle. Biomarker of metabolic acidosis. Human ortholog(s) of this gene implicated in several diseases, including auditory system disease (multiple); autosomal dominant Alport syndrome; blood platelet disease (multiple); end stage renal disease; and orofacial cleft. Orthologous to human MYH9 (Myosin heavy chain 9). [provided by Alliance of Genome Resources, Apr 2022]

MYH9 Products(2)

mRNA	Protein	Name
NM_001305877.1	NP_001292806.1	myosin-9
NM_013194.2	NP_037326.2	myosin-9

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G-protein alpha-subunit binding	IDA IDA: Inferred from direct assay	20068007	RGD
enables follicle-stimulating hormone receptor binding	IDA IDA: Inferred from direct assay	20068007	RGD
enables identical protein binding	IDA IDA: Inferred from direct assay	25131674	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15505042	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	19117932	RGD
enables scaffold protein binding	IDA IDA: Inferred from direct assay	21598299	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin filament bundle assembly	IMP IMP: Inferred from mutant phenotype	22992457	RGD
involved in actin filament bundle distribution	IMP IMP: Inferred from mutant phenotype	22992457	RGD
involved in cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	21598299	RGD
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	8888698	RGD
involved in cellular response to platelet-derived growth factor stimulus	IEP IEP: Inferred from expression pattern	8888698	RGD
involved in follicle-stimulating hormone signaling pathway	IMP IMP: Inferred from mutant phenotype	20068007	RGD
involved in negative regulation of vascular associated smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	21598299	RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20068007	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	23354122	RGD
involved in positive regulation of G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20068007	RGD
involved in positive regulation of endocytosis	IMP IMP: Inferred from mutant phenotype	19340093	RGD
involved in positive regulation of focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	21598299	RGD
involved in positive regulation of inositol trisphosphate biosynthetic process	IMP IMP: Inferred from mutant phenotype	20068007	RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	23354122	RGD
involved in positive regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	19117932	RGD
involved in regulation of actin filament organization	IMP IMP: Inferred from mutant phenotype	23354122	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin filament	IDA IDA: Inferred from direct assay	21598299	RGD
located in apical plasma membrane	IDA IDA: Inferred from direct assay	24042022	RGD
located in brush border	IDA IDA: Inferred from direct assay	22357915	RGD
located in endosome	IDA IDA: Inferred from direct assay	19340093	RGD
located in lamellipodium	IDA IDA: Inferred from direct assay	25131674	RGD
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	19117932	RGD
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	19117932	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	15823548	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

myosin-9

myosin heavy chain 9-like 1	myosin, heavy chain 9, non-muscle-like 1
nonmuscle myosin IIA

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08908	MYH9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18249	Myh9 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24729	Myh9 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	MYH9	NCBI	NCBI:4627

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