Cpe - carboxypeptidase E Gene

Rattus norvegicus

Also known as Cph; CARBE

Gene ID: 25669 | Gene type: protein coding

About Cpe

Summary

Enables Carboxypeptidase activity; cobalt ion binding activity; and protein domain specific binding activity. Involved in negative regulation of branching morphogenesis of a nerve and peptide metabolic process. Located in several cellular components, including membrane raft; perikaryon; and secretory granule. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CPE (Carboxypeptidase E). [provided by Alliance of Genome Resources, Apr 2022]

Cpe Products(1)

mRNA	Protein	Name
NM_013128.2	NP_037260.2	carboxypeptidase E precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables carboxypeptidase activity	IDA IDA: Inferred from direct assay	2822027	RGD
enables cobalt ion binding	IMP IMP: Inferred from mutant phenotype	2822027	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	2822027	RGD
enables protein domain specific binding	IDA IDA: Inferred from direct assay	19553464	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to dexamethasone stimulus	IMP IMP: Inferred from mutant phenotype	25426952	RGD
involved in cellular response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	25426952	RGD
involved in cellular response to staurosporine	IMP IMP: Inferred from mutant phenotype	25426952	RGD
involved in enkephalin processing	IDA IDA: Inferred from direct assay	6326144	RGD
involved in insulin processing	IDA IDA: Inferred from direct assay	2822027	RGD
involved in insulin processing	IMP IMP: Inferred from mutant phenotype	12829804	RGD
involved in insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	12829804	RGD
involved in negative regulation of branching morphogenesis of a nerve	IMP IMP: Inferred from mutant phenotype	19553464	RGD
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	25426952	RGD
involved in neuron migration	IMP IMP: Inferred from mutant phenotype	29982499	RGD
involved in neuron projection arborization	IMP IMP: Inferred from mutant phenotype	29982499	RGD
involved in peptide catabolic process	IDA IDA: Inferred from direct assay	2822027	RGD
involved in peptide metabolic process	IDA IDA: Inferred from direct assay	16219686	RGD
involved in protein processing	IDA IDA: Inferred from direct assay	2822027	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	19166515	RGD
located in dendrite	IDA IDA: Inferred from direct assay	17543468	RGD
located in dense core granule	IDA IDA: Inferred from direct assay	19553464	RGD
located in extracellular region	IDA IDA: Inferred from direct assay	10386951	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	10206965	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	17543468	RGD
located in nucleus	IDA IDA: Inferred from direct assay	25426952	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	17543468	RGD
located in secretory granule	IDA IDA: Inferred from direct assay	2822027	RGD
located in synaptic membrane	IDA IDA: Inferred from direct assay	19553464	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

carboxypeptidase E

carboxypeptidase H	enkephalin convertase
prohormone-processing carboxypeptidase

Related Agents

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12928	ML336	Inhibitor	99.09%	Unkown
HY-121528	Nilestriol		98.93%	Unkown
HY-132169	HCoV-229E-IN-1	Inhibitor	99.16%	Unkown
HY-12349	H1PVAT	Inhibitor	96.40%	Unkown
HY-106508	Fendosal	Inhibitor	/	Unkown
HY-124938	ABC-1		/	Unkown
HY-RS03090	CPE Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17120	Cpe Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23565	Cpe Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cpe	NCBI	NCBI:1363
Mus musculus	Cpe	NCBI	NCBI:12876

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