2. Gene
  3. Cpe - carboxypeptidase E Gene

Cpe - carboxypeptidase E Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CPH; fat; Cph1; Cph-1; NF-alpha1

Gene ID: 12876 | Gene type: protein coding

About Cpe

Summary

This gene encodes Carboxypeptidase E, a prohormone-processing exopeptidase found in secretory granules of endocrine and neuroendocrine cells. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional enzyme that cleaves the C-terminal basic residues of protein substrates. A missense mutation in this gene is responsible for the obesity phenotype in a mouse model known as the "fat mouse." Mice lacking the functional product of this gene exhibit impaired processing of multiple peptide Hormones such as proinsulin, prodynorphin, proneurotensin, promelanin-concentrating hormone and pro-opiomelanocortin. [provided by RefSeq, Jan 2016]

Cpe Products(1)

mRNA Protein Name
NM_013494.4 NP_038522.2 carboxypeptidase E preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables carboxypeptidase activity IMP
IMP: Inferred from mutant phenotype
7663508 MGI
enables metallocarboxypeptidase activity IMP
IMP: Inferred from mutant phenotype
9348219 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16219686 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within insulin processing IMP
IMP: Inferred from mutant phenotype
7663508 MGI
involved in insulin processing IMP
IMP: Inferred from mutant phenotype
9348219 MGI
acts upstream of or within peptide hormone secretion IMP
IMP: Inferred from mutant phenotype
16219686 MGI
acts upstream of or within protein localization to secretory granule IMP
IMP: Inferred from mutant phenotype
16219686 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in secretory granule IDA
IDA: Inferred from direct assay
9348219 MGI
located in secretory granule membrane IDA
IDA: Inferred from direct assay
16219686 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

carboxypeptidase E

carboxypeptidase H

enkephalin convertase

prohormone-processing carboxypeptidase

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12928 ML336 Inhibitor 99.09% Unkown
HY-121528 Nilestriol 98.93% Unkown
HY-132169 HCoV-229E-IN-1 Inhibitor 99.16% Unkown
HY-12349 H1PVAT Inhibitor 96.40% Unkown
HY-106508 Fendosal Inhibitor / Unkown
HY-124938 ABC-1 / Unkown
HY-RS03090 CPE Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17120 Cpe Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23565 Cpe Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cpe NCBI NCBI:1363