Gnai3 - G protein subunit alpha i3 Gene

Rattus norvegicus

Also known as GIP3A

Gene ID: 25643 | Gene type: protein coding

About Gnai3

Summary

Enables G protein-coupled serotonin receptor binding activity; GTPase activating protein binding activity; and protein domain specific binding activity. Involved in several processes, including positive regulation of NAD(P)H oxidase activity; positive regulation of superoxide anion generation; and positive regulation of vascular associated smooth muscle cell proliferation. Located in membrane raft; plasma membrane; and zymogen granule. Biomarker of hypertension. Orthologous to human GNAI3 (G protein subunit alpha i3). [provided by Alliance of Genome Resources, Apr 2022]

Gnai3 Products(1)

mRNA	Protein	Name
NM_013106.2	NP_037238.1	guanine nucleotide-binding protein G(i) subunit alpha-3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled serotonin receptor binding	IPI IPI: Inferred from physical interaction	16772521	RGD
enables GTPase activating protein binding	IPI IPI: Inferred from physical interaction	11387333	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	8524874	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	11387333	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	25633408	RGD
involved in positive regulation of NAD(P)H oxidase activity	IMP IMP: Inferred from mutant phenotype	27912212	RGD
involved in positive regulation of superoxide anion generation	IMP IMP: Inferred from mutant phenotype	27912212	RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	27912212	RGD
involved in vesicle fusion	IDA IDA: Inferred from direct assay	12038977	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	11387333	RGD
located in zymogen granule	IDA IDA: Inferred from direct assay	12038977	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

guanine nucleotide-binding protein G(i) subunit alpha-3

Guanine nucleotide binding, protein, alpha inhibiting polypeptide 3	g(i) alpha-3
guanine nucleotide binding protein (G protein), alpha inhibiting 3	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
guanine nucleot

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05536	GNAI3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20413	Gnai3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26922	Gnai3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gnai3	NCBI	NCBI:2773

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