Agrn - agrin Gene

Rattus norvegicus

Also known as AGR

Gene ID: 25592 | Gene type: protein coding

About Agrn

Summary

Enables calcium ion binding activity; cytokine binding activity; and dystroglycan binding activity. Involved in several processes, including positive regulation of filopodium assembly; positive regulation of nitrogen compound metabolic process; and synapse organization. Acts upstream of or within receptor clustering. Located in axonal growth cone; basement membrane; and synapse. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 8. Orthologous to human AGRN (agrin). [provided by Alliance of Genome Resources, Apr 2022]

Agrn Products(1)

mRNA	Protein	Name
NM_175754.2	NP_786930.2	agrin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables BMP binding	IPI IPI: Inferred from physical interaction	20505824	RGD
enables calcium ion binding	IDA IDA: Inferred from direct assay	20566625	RGD
enables dystroglycan binding	IDA IDA: Inferred from direct assay	8693000	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	8205617	RGD
enables transforming growth factor beta binding	IPI IPI: Inferred from physical interaction	20505824	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	15883200	RGD
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	20471381	RGD
involved in positive regulation of filopodium assembly	IDA IDA: Inferred from direct assay	20471381	RGD
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	18957220	RGD
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	22302937	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12796478	RGD
acts upstream of or within receptor clustering	IDA IDA: Inferred from direct assay	15155732	RGD
involved in regulation of axon guidance	IDA IDA: Inferred from direct assay	17870250	RGD
involved in regulation of microtubule cytoskeleton organization	IDA IDA: Inferred from direct assay	17870250	RGD
involved in regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	18848351	RGD
involved in regulation of synapse organization	IDA IDA: Inferred from direct assay	19524020	RGD
involved in regulation of synapse organization	IMP IMP: Inferred from mutant phenotype	19524020	RGD
involved in skeletal muscle acetylcholine-gated channel clustering	IDA IDA: Inferred from direct assay	18957220	RGD
involved in skeletal muscle acetylcholine-gated channel clustering	IMP IMP: Inferred from mutant phenotype	22302937	RGD
involved in synapse assembly	IMP IMP: Inferred from mutant phenotype	12486121	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axonal growth cone	IDA IDA: Inferred from direct assay	14697677	RGD
located in basement membrane	IDA IDA: Inferred from direct assay	15711988	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	19524020	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	19524020	RGD
located in synapse	IDA IDA: Inferred from direct assay	12796478	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

agrin

Agrn Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Agrn	P25304	Lrp4	Mus musculus	Q8VI56	Pull Down	18848351

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00464	AGRN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19873	Agrn Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26372	Agrn Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Agrn	NCBI	NCBI:375790

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