Pax6 - paired box 6 Gene

Rattus norvegicus

Gene ID: 25509 | Gene type: protein coding

About Pax6

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and minor groove of adenine-thymine-rich DNA binding activity. Involved in several processes, including cellular response to hormone stimulus; enteroendocrine cell differentiation; and nervous system development. Located in chromatin and nucleus. Used to study autistic disorder. Biomarker of Smith-Lemli-Opitz syndrome and transient cerebral ischemia. Human ortholog(s) of this gene implicated in bilateral optic nerve hypoplasia; eye disease (multiple); glucose intolerance; and paranoid schizophrenia. Orthologous to human PAX6 (paired box 6). [provided by Alliance of Genome Resources, Apr 2022]

Pax6 Products(1)

mRNA	Protein	Name
NM_013001.2	NP_037133.1	paired box protein Pax-6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	20592023	RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20592023	RGD
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	12370174	RGD
enables minor groove of adenine-thymine-rich DNA binding	IDA IDA: Inferred from direct assay	12370174	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12370174	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in astrocyte differentiation	IMP IMP: Inferred from mutant phenotype	22944581	RGD
involved in cellular response to fibroblast growth factor stimulus	IEP IEP: Inferred from expression pattern	18189319	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	21818840	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	18189319	RGD
involved in cellular response to prostaglandin E stimulus	IEP IEP: Inferred from expression pattern	23257891	RGD
involved in cellular response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	19619535	RGD
involved in cerebellum development	IEP IEP: Inferred from expression pattern	11688562	RGD
involved in epithelial cell development	IMP IMP: Inferred from mutant phenotype	19393751	RGD
involved in hindbrain development	IDA IDA: Inferred from direct assay	11880342	RGD
involved in hindbrain development	IMP IMP: Inferred from mutant phenotype	20082710	RGD
involved in insulin metabolic process	IMP IMP: Inferred from mutant phenotype	21069736	RGD
involved in interkinetic nuclear migration	IMP IMP: Inferred from mutant phenotype	17825043	RGD
involved in learned vocalization behavior or vocal learning	IMP IMP: Inferred from mutant phenotype	21203536	RGD
involved in neural crest cell migration	IMP IMP: Inferred from mutant phenotype	9079035	RGD
involved in neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	22944581	RGD
involved in neuron migration	IMP IMP: Inferred from mutant phenotype	12534968	RGD
involved in olfactory bulb development	IMP IMP: Inferred from mutant phenotype	14736749	RGD
involved in olfactory bulb mitral cell layer development	IMP IMP: Inferred from mutant phenotype	14736749	RGD
involved in pancreatic A cell development	IMP IMP: Inferred from mutant phenotype	20592023	RGD
involved in pancreatic A cell differentiation	IMP IMP: Inferred from mutant phenotype	20592023	RGD
involved in positive regulation of cell fate specification	IMP IMP: Inferred from mutant phenotype	11880342	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	11222774	RGD
involved in positive regulation of glutamatergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	24030726	RGD
involved in positive regulation of neuron migration	IGI IGI: Inferred from genetic interaction	11688562	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20592023	RGD
involved in regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	16164600	RGD
involved in regulation of neuron differentiation	IDA IDA: Inferred from direct assay	11880342	RGD
involved in regulation of neuron projection development	IGI IGI: Inferred from genetic interaction	11688562	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	21073715	RGD
involved in retina development in camera-type eye	IEP IEP: Inferred from expression pattern	19012751	RGD
involved in rhombomere morphogenesis	IMP IMP: Inferred from mutant phenotype	21501682	RGD
involved in sensory neuron migration	IMP IMP: Inferred from mutant phenotype	16510508	RGD
involved in spinal cord development	IEP IEP: Inferred from expression pattern	20195794	RGD
involved in type B pancreatic cell differentiation	IMP IMP: Inferred from mutant phenotype	22403172	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	20592023	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

paired box protein Pax-6

oculorhombin	paired box gene 6
paired box homeotic gene 6

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10093	PAX6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20319	Pax6 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26827	Pax6 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pax6	NCBI	NCBI:5080

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