2. Gene
  3. PAM - Pam peptidylglycine alpha-amidating monooxygenase Gene

PAM - Pam peptidylglycine alpha-amidating monooxygenase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as PHM

Gene ID: 25508 | Gene type: protein coding

About PAM

Summary

Enables several functions, including metal ion binding activity; peptidylamidoglycolate lyase activity; and peptidylglycine monooxygenase activity. Involved in several processes, including animal organ development; fatty acid primary amide biosynthetic process; and peptide amidation. Located in several cellular components, including perikaryon; secretory granule membrane; and trans-Golgi network. Biomarker of hypothyroidism. Orthologous to human PAM (peptidylglycine alpha-amidating monooxygenase). [provided by Alliance of Genome Resources, Apr 2022]

PAM Products(1)

mRNA Protein Name
NM_013000.3 NP_037132.2 peptidylglycine alpha-amidating monooxygenase precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
19604476 RGD
enables copper ion binding IDA
IDA: Inferred from direct assay
10504734 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
11395514 RGD
enables peptidylamidoglycolate lyase activity IDA
IDA: Inferred from direct assay
10079066 RGD
enables peptidylglycine monooxygenase activity IDA
IDA: Inferred from direct assay
10079066 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
8910496 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
8910496 RGD
enables zinc ion binding IDA
IDA: Inferred from direct assay
19604476 RGD
Biological Process GO Annotation Evidence Reference Source
involved in fatty acid primary amide biosynthetic process IDA
IDA: Inferred from direct assay
10079066 RGD
involved in heart development IEP
IEP: Inferred from expression pattern
9441675 RGD
involved in lactation IEP
IEP: Inferred from expression pattern
16448835 RGD
involved in limb development IEP
IEP: Inferred from expression pattern
9441675 RGD
involved in long-chain fatty acid metabolic process IDA
IDA: Inferred from direct assay
8660675 RGD
involved in maternal process involved in female pregnancy IEP
IEP: Inferred from expression pattern
9441675 RGD
involved in ovulation cycle process IEP
IEP: Inferred from expression pattern
9618561 RGD
involved in peptide amidation IDA
IDA: Inferred from direct assay
2999151 RGD
involved in peptide metabolic process IDA
IDA: Inferred from direct assay
18818385 RGD
involved in regulation of actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
11251076 RGD
involved in regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20573687 RGD
involved in response to copper ion IEP
IEP: Inferred from expression pattern
15629125 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
9618561 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
10347250 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
18818385 RGD
involved in response to pH IDA
IDA: Inferred from direct assay
11395514 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
10347250 RGD
involved in toxin metabolic process IDA
IDA: Inferred from direct assay
12721493 RGD
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
15905171 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
16448835 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
20202202 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
8910496 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
8663411 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
15539631 RGD
located in trans-Golgi network IDA
IDA: Inferred from direct assay
20573687 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

peptidylglycine alpha-amidating monooxygenase

basic salivary proline-rich protein 4-like

peptidyl-glycine alpha-amidating monooxygenase

Related Agents

Approval
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-A0106 Levamisole 99.96% Yes
HY-B0288B Fenoprofen Calcium hydrate 99.69% Unkown
HY-B1200 Pralidoxime chloride Activator 99.73% Unkown
HY-B1456A Fenoprofen 99.70% Unkown
HY-B0288A Fenoprofen Calcium / Unkown
HY-B0288BR Fenoprofen Calcium hydrate (Standard) / Unkown
Clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-128770 LY3154207 Agonist 99.87% Phase 2
HY-111052 AZD7325 99.71% Phase 2
HY-120874 PF-06372865 Activator 99.29% Phase 2
HY-132806 Alogabat Agonist 99.93% Phase 2
HY-108703 Foliglurax Agonist / Phase 2
HY-144291 LY3154885 Agonist / Phase 1
Pre-clinical Phase
Bioactive Molecules (152)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P1180A Pam3CSK4 TFA Agonist 99.66% Unkown
HY-108471 CU-CPT22 Inhibitor ≥99.0% Unkown
HY-110279 Ogerin Modulator 99.58% Unkown
HY-112146 MMG-11 Antagonist 99.24% Unkown
HY-115467 MitoBloCK-10 98.99% Unkown
HY-113320 Etiocholanolone Modulator 99.35% Unkown
HY-120023 VU0453595 Agonist 99.90% Unkown
HY-108703A Foliglurax monohydrochloride Agonist 98.93% Yes
HY-143312 V-0219 Modulator 99.86% Unkown
HY-120613 BMS-986187 Activator 98.93% Unkown
HY-129086 BPAM344 Agonist 99.66% Unkown
HY-18654 ADX88178 Agonist 99.69% Unkown
HY-P1181A Pam2CSK4 TFA Agonist 99.28% Unkown
HY-12158 VU0238441 Activator 99.88% Unkown
HY-124419 RO0711401 Agonist 98.42% Unkown
HY-113346 Tetrahydrodeoxycorticosterone Agonist 99.45% Unkown
HY-114933 VU0119498 Modulator 99.52% Unkown
HY-13058 ADX-47273 Agonist 99.94% Unkown
HY-131004 CB2R PAM Agonist 98.46% Unkown
HY-143312A V-0219 hydrochloride Modulator 99.65% Unkown
HY-116819 VU0453379 Modulator ≥98.0% Unkown
HY-116819A VU0453379 hydrochloride Modulator ≥99.0% Unkown
HY-100588 VU0364770 Agonist 99.94% Unkown
HY-122255 LY487379 Inhibitor 98.92% Unkown
HY-12439 ML380 Agonist 99.91% Unkown
HY-14418 VU0361737 Agonist 99.79% Unkown
HY-100605 VU0483605 Modulator 97.30% Unkown
HY-103475 GS39783 Agonist 99.72% Unkown
HY-136190 TRPC6-PAM-C20 Agonist 99.78% Unkown
HY-14417 VU0155041 Agonist 99.10% Unkown
HY-14612 CPPHA Modulator 98.04% Unkown
HY-W141789 Pam3-Cys-OH 99.89% Unkown
HY-112146A MMG-11 quarterhydrate Antagonist 98.70% Unkown
HY-143312E (S)-V-0219 hydrochloride Modulator 99.71% Unkown
HY-148867 UCM-1306 Modulator 99.61% Unkown
HY-149453 MCUF-651 Modulator 99.85% Unkown
HY-113689 GAT211 Agonist 99.98% Unkown
HY-117851 AC-265347 Agonist 99.97% Unkown
HY-120184 VU0467485 Agonist ≥99.0% Unkown
HY-120530 JNJ-46281222 Inhibitor 98.77% Unkown
HY-124821 VA012 Modulator 99.34% Unkown
HY-139044 VU6000918 Activator 99.36% Unkown
HY-143312D (R)-V-0219 hydrochloride Modulator 99.37% Unkown
HY-162455 NA-014 Agonist 99.49% Unkown
HY-W115727A Polyacrylamide,Anion,Mw 14-16 million / Unkown
HY-W115727B Polyacrylamide,Anion,Mw 18 million ≥98.0% Unkown
HY-113346S Tetrahydrodeoxycorticosterone-d3 Agonist 98.50% Unkown
HY-15476 VU 0364439 Agonist 99.42% Unkown
HY-113320S Etiocholanolone-d5 Modulator 99.20% Unkown
HY-114978 VU0424465 Agonist 99.84% Unkown
HY-116463 E1R Agonist 99.83% Unkown
HY-117408 VU6004256 Modulator 99.61% Unkown
HY-119078 VU0080241 Modulator 99.69% Unkown
HY-122819 Calindol hydrochloride Agonist 99.88% Unkown
HY-126327 UNC4976 Antagonist / Unkown
HY-137204 COR659 Activator 99.94% Unkown
HY-156331 VU6004909 Activator 99.40% Unkown
HY-12149 A-867744 Agonist 99.76% Unkown
HY-W338852 Gentisuric acid 99.65% Unkown
HY-101841 LY 2033298 Activator 99.87% Unkown
HY-114863 PHCCC(4Me) Modulator 99.99% Unkown
HY-116855 TASP0433864 Modulator 99.9% Unkown
HY-118179 VU0486321 Agonist 99.30% Unkown
HY-118416 BMS-986124 Antagonist 99.00% Unkown
HY-119226 VU0152099 Agonist 98.25% Unkown
HY-121806 VU0486846 Modulator 99.20% Unkown
HY-126327A UNC4976 TFA Antagonist ≥98.0% Unkown
HY-141515 BMS-986121 Modulator 98.89% Unkown
HY-14419 TCN238 Modulator 99.57% Unkown
HY-16951 VU-1545 Agonist 99.00% Unkown
HY-P1180 Pam3CSK4 Agonist / Unkown
HY-11048 NS11394 Modulator 99.77% Unkown
HY-15393 VU 0357121 Agonist 99.73% Unkown
HY-112814 VU6001376 / Unkown
HY-128584 VU6005806 Agonist / Unkown
HY-103552 LY487379 hydrochloride Modulator / Unkown
HY-103571 VU0285683 Antagonist / Unkown
HY-107423 GNE 6901 Agonist / Unkown
HY-107504 VU0360172 hydrochloride Agonist 98.94% Unkown
HY-107506 Ro 67-4853 Agonist 99.90% Unkown
HY-108340 PF-06767832 Agonist / Unkown
HY-113320S1 Etiocholanolone-d2 Modulator / Unkown
HY-113608 VCP171 Modulator / Unkown
HY-116149 A-424274 Agonist / Unkown
HY-116463A (2R,3S)-E1R Agonist 98.84% Unkown
HY-116463B (2S,3S)-E1R Agonist 98.24% Unkown
HY-116463C (2R,3R)-E1R Agonist 98.79% Unkown
HY-116463D (Rac)-E1R Agonist 98.48% Unkown
HY-117611 GAT107 Modulator / Unkown
HY-118022 VU0361747 / Unkown
HY-118256 LSN2814617 Modulator / Unkown
HY-120004 PF-06827443 / Unkown
HY-120576 ML169 Modulator / Unkown
HY-120727 VU0364289 Activator 99.52% Unkown
HY-124112 PAM 1392 Inhibitor / Unkown
HY-124372 JNJ-46356479 Modulator / Unkown
HY-128783 VU0090157 Modulator / Unkown
HY-134912 CMPPE Modulator / Unkown
HY-136258 nAChR agonist CMPI hydrochloride Agonist / Unkown
HY-143312B (R)-V-0219 Modulator / Unkown
HY-143312C (S)-V-0219 Modulator / Unkown
HY-14417B VU0155041 sodium Agonist / Unkown
HY-147421 Xilmenolone Modulator / Unkown
HY-149975 AMPA receptor modulator-4 Activator / Unkown
HY-151899 A3AR modulator 1 Agonist / Unkown
HY-155628 AMPA receptor modulator-6 Modulator / Unkown
HY-157421 Nampt activator-4 Modulator / Unkown
HY-159177 M4 mAChR Modulator-1 Modulator / Unkown
HY-159509 Claziprotamidum Modulator / Unkown
HY-159624 KK-92A Modulator / Unkown
HY-160529 α7 nAChR Modulator-2 Modulator / Unkown
HY-161810 MRS8247 Modulator / Unkown
HY-162454 DA-023 Modulator / Unkown
HY-162662 VU6008677 / Unkown
HY-163280 JGB-1-155 Activator / Unkown
HY-168025 VU6007496 Modulator / Unkown
HY-169247 Pam2CS-DMAPA / Unkown
HY-169329 BIO-2007817 Modulator 99.35% Unkown
HY-170499 VU6024578 Agonist / Unkown
HY-170903 GABAA receptor modulator-3 Agonist / Unkown
HY-173032 VU6033685 Agonist / Unkown
HY-173251S ENX-101 Modulator / Unkown
HY-173396 VU0467319 Modulator / Unkown
HY-18679 TC-N 22A Agonist / Unkown
HY-19623 VU0092273 Agonist / Unkown
HY-B1456AS Fenoprofen-13C6 sodium hydrate / Unkown
HY-P1180B Pam3CSK4 trihydrochloride / Unkown
HY-P1181 Pam2CSK4 Agonist / Unkown
HY-P1405 Pam3CSK4-Biotin Agonist / Unkown
HY-P4802 Pam3-Cys-Ala-Gly Inhibitor / Unkown
HY-RS10011 PAM Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10012 PAM16 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W115727 Polyacrylamide,Anion,Mw 10-12 million / Unkown
HY-103535 GBLD345 Agonist / Unkown
HY-111332 (E)-PHCCC Modulator / Unkown
HY-119772 VU0366369 Modulator / Unkown
HY-121600 GAT229 Modulator / Unkown
HY-122164 LY-503430 Agonist / Unkown
HY-123667 NCFP Modulator / Unkown
HY-123934 VU6007477 Modulator / Unkown
HY-129517 UBP714 Agonist / Unkown
HY-155467 MRS7935 Modulator / Unkown
HY-161113 Z8554052021 Activator / Unkown
HY-161118 MB327 / Unkown
HY-167922 (R,R,S)-GAT107 / Unkown
HY-173356 Antiparasitic agent-26 Inhibitor / Unkown
HY-RS16569 Pam Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19468 Pam16 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23002 Pam Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25961 Pam16 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W115727D Polyacrylamide,average Mn 40000 / Unkown
HY-W115727E Polyacrylamide,average Mn 150000 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens PAM NCBI NCBI:5066
Mus musculus PAM NCBI NCBI:18484