Oxt - oxytocin/neurophysin I prepropeptide Gene

Rattus norvegicus

Gene ID: 25504 | Gene type: protein coding

About Oxt

Summary

Enables neuropeptide hormone activity and Oxytocin Receptor binding activity. Involved in several processes, including mating; positive regulation of smooth muscle contraction; and regulation of secretion. Located in extracellular space; secretory granule; and terminal bouton. Used to study gastric ulcer and hypertension. Biomarker of hypertension. Orthologous to human OXT (oxytocin/neurophysin I prepropeptide). [provided by Alliance of Genome Resources, Apr 2022]

Oxt Products(1)

mRNA	Protein	Name
NM_012996.3	NP_037128.1	oxytocin-neurophysin 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables neuropeptide hormone activity	IDA IDA: Inferred from direct assay	19560475	RGD
enables oxytocin receptor binding	IDA IDA: Inferred from direct assay	15821089	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15927785	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in drinking behavior	IDA IDA: Inferred from direct assay	15380376	RGD
involved in eating behavior	IDA IDA: Inferred from direct assay	15380376	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	18936075	RGD
involved in grooming behavior	IDA IDA: Inferred from direct assay	17505467	RGD
involved in heart development	IEP IEP: Inferred from expression pattern	15316117	RGD
involved in male mating behavior	IEP IEP: Inferred from expression pattern	18655888	RGD
involved in maternal aggressive behavior	IEP IEP: Inferred from expression pattern	18655888	RGD
involved in maternal behavior	IDA IDA: Inferred from direct assay	18513132	RGD
involved in memory	IEP IEP: Inferred from expression pattern	18304743	RGD
involved in negative regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	18562099	RGD
involved in negative regulation of urine volume	IDA IDA: Inferred from direct assay	18057218	RGD
involved in positive regulation of blood pressure	IDA IDA: Inferred from direct assay	19120122	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	10497238	RGD
involved in positive regulation of female receptivity	IDA IDA: Inferred from direct assay	11264328	RGD
involved in positive regulation of hindgut contraction	IDA IDA: Inferred from direct assay	19258489	RGD
involved in positive regulation of norepinephrine secretion	IDA IDA: Inferred from direct assay	14656297	RGD
involved in positive regulation of ossification	IDA IDA: Inferred from direct assay	18257653	RGD
involved in positive regulation of penile erection	IDA IDA: Inferred from direct assay	18671741	RGD
involved in positive regulation of prostaglandin secretion	IDA IDA: Inferred from direct assay	9575824	RGD
involved in positive regulation of synapse assembly	IDA IDA: Inferred from direct assay	16488155	RGD
involved in positive regulation of synaptic transmission	IDA IDA: Inferred from direct assay	17314286	RGD
involved in positive regulation of uterine smooth muscle contraction	IDA IDA: Inferred from direct assay	19164477	RGD
involved in regulation of heart rate	IDA IDA: Inferred from direct assay	3668162	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	16157794	RGD
involved in response to amphetamine	IEP IEP: Inferred from expression pattern	17383105	RGD
involved in response to cAMP	IEP IEP: Inferred from expression pattern	11168841	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	18609307	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	18823708	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	19258489	RGD
involved in response to ether	IEP IEP: Inferred from expression pattern	1943445	RGD
involved in response to food	IEP IEP: Inferred from expression pattern	18832082	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	17553493	RGD
involved in response to organic cyclic compound	IDA IDA: Inferred from direct assay	19248249	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	12504828	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	19246538	RGD
involved in response to progesterone	IDA IDA: Inferred from direct assay	17280592	RGD
involved in response to prostaglandin E	IEP IEP: Inferred from expression pattern	19017254	RGD
involved in response to retinoic acid	IEP IEP: Inferred from expression pattern	15316117	RGD
involved in response to steroid hormone	IEP IEP: Inferred from expression pattern	12588901	RGD
involved in response to sucrose	IEP IEP: Inferred from expression pattern	19022308	RGD
involved in social behavior	IDA IDA: Inferred from direct assay	17540347	RGD
involved in sperm ejaculation	IDA IDA: Inferred from direct assay	18552879	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	18953097	RGD
is active in neuronal dense core vesicle	IDA IDA: Inferred from direct assay	3883189	RGD
located in secretory granule	IDA IDA: Inferred from direct assay	11456414	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	18987209	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

oxytocin-neurophysin 1

OT-NPI	oxcytocin
oxytocin, prepropeptide	oxytocin/neurophysin (Oxt) gene, complete gene, complete cds
oxytocin/neurophysin 1 prepropeptide

Oxt Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87000	Oxytocin-neurophysin 1/OXT Antibody (YA6693)	IHC-F, IF-Tissue	Mouse, Rat

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P4990A	Pro8-Oxytocin TFA	Activator	99.68%	Unkown
HY-P4990	Pro8-Oxytocin	Activator	/	Unkown
HY-RS09893	OXT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18742	Oxt Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25229	Oxt Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Oxt	NCBI	NCBI:5020

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