Npm1 - nucleophosmin 1 Gene

Rattus norvegicus

Also known as B23NP

Gene ID: 25498 | Gene type: protein coding

About Npm1

Summary

Enables several functions, including anion binding activity; p53 binding activity; and protein kinase B binding activity. Involved in several processes, including RNA metabolic process; negative regulation of apoptotic process; and regulation of DNA replication. Located in cytoplasm and nuclear lumen. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human NPM1 (nucleophosmin 1). [provided by Alliance of Genome Resources, Apr 2022]

Npm1 Products(1)

mRNA	Protein	Name
NM_012992.4	NP_037124.1	nucleophosmin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IMP IMP: Inferred from mutant phenotype	19123973	RGD
enables DNA binding	IDA IDA: Inferred from direct assay	8611572	RGD
enables enzyme binding	IDA IDA: Inferred from direct assay	11481036	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	15893727	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	8611572	RGD
enables p53 binding	IPI IPI: Inferred from physical interaction	15872011	RGD
enables phosphatidylinositol-3,4,5-trisphosphate binding	IPI IPI: Inferred from physical interaction	15893727	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10220582	RGD
enables protein kinase B binding	IDA IDA: Inferred from direct assay	18931307	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cardiac muscle hypertrophy	IEP IEP: Inferred from expression pattern	21444791	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	21444791	RGD
involved in cellular response to testosterone stimulus	IEP IEP: Inferred from expression pattern	8287071	RGD
involved in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IDA IDA: Inferred from direct assay	9742256	RGD
involved in liver regeneration	IEP IEP: Inferred from expression pattern	14635188	RGD
involved in negative regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	21444791	RGD
involved in negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	15872011	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	19123973	RGD
involved in positive regulation of DNA metabolic process	IDA IDA: Inferred from direct assay	11481036	RGD
involved in positive regulation of DNA replication	IDA IDA: Inferred from direct assay	11481036	RGD
involved in positive regulation of DNA-directed DNA polymerase activity	IDA IDA: Inferred from direct assay	8123045	RGD
involved in positive regulation of catalytic activity	IDA IDA: Inferred from direct assay	11481036	RGD
involved in rRNA transcription	IMP IMP: Inferred from mutant phenotype	21444791	RGD
involved in regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	15893727	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in nuclear matrix	IDA IDA: Inferred from direct assay	20387789	RGD
located in nucleoplasm	IDA IDA: Inferred from direct assay	14635188	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nucleophosmin

NPM	nucleolar phosphoprotein B23
nucleolar protein B23.1	nucleolar protein NO38
nucleophosmin (nucleolar phosphoprotein B23, numatrin)	numatrin

Related Agents

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136360	MI-3454	Inhibitor	98.03%	Unkown
HY-162265A	UCM-13369 dihydrochloride	Inducer	99.87%	Unkown
HY-N10264	Avrainvillamide		95.00%	Unkown
HY-162265	UCM-13369	Inducer	/	Unkown
HY-114162B	VTP50469 mesylate		/	Unkown
HY-164279	YTR107		/	Unkown
HY-RS09490	NPM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17071	Npm1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18762	Gja1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23515	Npm1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Npm1	NCBI	NCBI:4869
Mus musculus	Npm1	NCBI	NCBI:18148

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