2. Gene
  3. Mip - major intrinsic protein of lens fiber Gene

Mip - major intrinsic protein of lens fiber Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Aqp0

Gene ID: 25480 | Gene type: protein coding

About Mip

Summary

Enables water channel activity. Involved in canalicular bile acid transport and water transport. Located in intracellular canaliculus and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in cataract and cataract 15 multiple types. Orthologous to human MIP (major intrinsic protein of lens fiber). [provided by Alliance of Genome Resources, Apr 2022]

Mip Products(1)

mRNA Protein Name
NM_001105719.2 NP_001099189.1 lens fiber major intrinsic protein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables water channel activity IDA
IDA: Inferred from direct assay
11932260 RGD
Biological Process GO Annotation Evidence Reference Source
involved in canalicular bile acid transport IDA
IDA: Inferred from direct assay
11932260 RGD
involved in water transport IDA
IDA: Inferred from direct assay
11932260 RGD
Cellular Component GO Annotation Evidence Reference Source
located in intracellular canaliculus IDA
IDA: Inferred from direct assay
11932260 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lens fiber major intrinsic protein

MIP26

MP26

aquaporin-0

major intrinsic protein of eye lens fiber

Related Agents

Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-B0498 Bindarit Inhibitor 99.53% Phase 3
HY-B0155 Vicriviroc / Phase 3
HY-19974 TAK-220 99.95% Phase 1
HY-P3627 Nagrestipen / Phase 1
Pre-clinical Phase
Bioactive Molecules (21)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-139644 MIPS521 Agonist 98.21% Unkown
HY-156371 MIPS-21335 Inhibitor 99.61% Unkown
HY-P4191A Met-RANTES (human) (acetate) Antagonist 99.62% Unkown
HY-149650 TLR4 agonist-1 Agonist / Unkown
HY-P4191 Met-RANTES (human) Antagonist / Unkown
HY-W014081 Ethyl 3-coumarincarboxylate 99.81% Unkown
HY-123661 MIPS1455 / Unkown
HY-123733 MIP-1095 Inhibitor / Unkown
HY-123733A MIP-1095 TFA 99.76% Unkown
HY-129615 MIP-1072 Inhibitor / Unkown
HY-149650A TLR4 agonist-1 TEA Agonist / Unkown
HY-149861 Mip-IN-1 Inhibitor / Unkown
HY-15544 CCR1 antagonist 10 Antagonist / Unkown
HY-161901 BC-1293 Inhibitor / Unkown
HY-B0155B Vicriviroc malate / Unkown
HY-RS08460 MIP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-103360B trans-J-113863 Antagonist / Unkown
HY-120265 MIPS-9922 Inhibitor / Unkown
HY-168149 Mip-IN-2 Inhibitor / Unkown
HY-RS19300 Mip Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25791 Mip Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mip NCBI NCBI:4284
Mus musculus Mip NCBI NCBI:17339
Macaca mulatta Mip NCBI NCBI:712901