2. Gene
  3. Mip - major intrinsic protein of lens fiber Gene

Mip - major intrinsic protein of lens fiber Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Cat; Cts; Hfi; Lop; Svl; Aqp0; MP26; MIP26; shrivelled

Gene ID: 17339 | Gene type: protein coding

About Mip

Summary

Enables water channel activity. A structural constituent of eye lens. Acts upstream of or within lens development in camera-type eye; visual perception; and water transport. Located in plasma membrane. Is expressed in several structures, including eye; femur; and main olfactory bulb. Used to study cataract 15 multiple types. Human ortholog(s) of this gene implicated in cataract and cataract 15 multiple types. Orthologous to human MIP (major intrinsic protein of lens fiber). [provided by Alliance of Genome Resources, Apr 2022]

Mip Products(1)

mRNA Protein Name
NM_008600.5 NP_032626.2 lens fiber major intrinsic protein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
18056999 MGI
enables structural constituent of eye lens IDA
IDA: Inferred from direct assay
11773604 MGI
enables water channel activity IMP
IMP: Inferred from mutant phenotype
11773604 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within lens development in camera-type eye IMP
IMP: Inferred from mutant phenotype
7333462 MGI
acts upstream of or within visual perception IMP
IMP: Inferred from mutant phenotype
11773604 MGI
acts upstream of or within water transport IMP
IMP: Inferred from mutant phenotype
11773604 MGI
Cellular Component GO Annotation Evidence Reference Source
located in membrane IDA
IDA: Inferred from direct assay
17377981 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
9620080 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lens fiber major intrinsic protein

aquaporin-0

cataract and small eye

dominant cataract

hydropic fibers

lens opacity

major intrinsic protein of eye lens fiber

Related Agents

Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-B0498 Bindarit Inhibitor 99.53% Phase 3
HY-B0155 Vicriviroc / Phase 3
HY-19974 TAK-220 99.95% Phase 1
HY-P3627 Nagrestipen / Phase 1
Pre-clinical Phase
Bioactive Molecules (21)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-139644 MIPS521 Agonist 98.21% Unkown
HY-156371 MIPS-21335 Inhibitor 99.61% Unkown
HY-P4191A Met-RANTES (human) (acetate) Antagonist 99.62% Unkown
HY-149650 TLR4 agonist-1 Agonist / Unkown
HY-P4191 Met-RANTES (human) Antagonist / Unkown
HY-W014081 Ethyl 3-coumarincarboxylate 99.81% Unkown
HY-123661 MIPS1455 / Unkown
HY-123733 MIP-1095 Inhibitor / Unkown
HY-123733A MIP-1095 TFA 99.76% Unkown
HY-129615 MIP-1072 Inhibitor / Unkown
HY-149650A TLR4 agonist-1 TEA Agonist / Unkown
HY-149861 Mip-IN-1 Inhibitor / Unkown
HY-15544 CCR1 antagonist 10 Antagonist / Unkown
HY-161901 BC-1293 Inhibitor / Unkown
HY-B0155B Vicriviroc malate / Unkown
HY-RS08460 MIP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-103360B trans-J-113863 Antagonist / Unkown
HY-120265 MIPS-9922 Inhibitor / Unkown
HY-168149 Mip-IN-2 Inhibitor / Unkown
HY-RS19300 Mip Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25791 Mip Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mip NCBI NCBI:4284
Rattus norvegicus Mip NCBI NCBI:25480
Macaca mulatta Mip NCBI NCBI:712901