Kcna4 - potassium voltage-gated channel subfamily A member 4 Gene

Rattus norvegicus

Also known as Kv4; RK3; RHK1; KCHAN; Kv1.4

Gene ID: 25469 | Gene type: protein coding

About Kcna4

Summary

Enables voltage-gated Potassium Channel activity. Involved in potassium ion transmembrane transport. Located in several cellular components, including asymmetric synapse; cell surface; and dendrite. Is integral component of plasma membrane. Part of voltage-gated Potassium Channel complex. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Orthologous to human KCNA4 (potassium voltage-gated channel subfamily A member 4). [provided by Alliance of Genome Resources, Apr 2022]

Kcna4 Products(1)

mRNA	Protein	Name
NM_012971.3	NP_037103.2	potassium voltage-gated channel subfamily A member 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables monoatomic ion channel activity	IDA IDA: Inferred from direct assay	2384173	RGD
enables potassium channel activity	IDA IDA: Inferred from direct assay	2384173	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	7477295	RGD
enables voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	2384173	RGD
enables voltage-gated potassium channel activity	IMP IMP: Inferred from mutant phenotype	2555158	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in potassium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	2555158	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in asymmetric synapse	IDA IDA: Inferred from direct assay	14615029	RGD
located in axon	IDA IDA: Inferred from direct assay	8361540	RGD
located in cell surface	IDA IDA: Inferred from direct assay	21943416	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	14615029	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	14615029	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	14615029	RGD
located in membrane	IDA IDA: Inferred from direct assay	8361540	RGD
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	2555158	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	14615029	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	14615029	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	14615029	RGD
located in presynaptic membrane	IDA IDA: Inferred from direct assay	14615029	RGD
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	9334400	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

potassium voltage-gated channel subfamily A member 4

RCK4	potassium channel, voltage gated shaker related subfamily A, member 4
potassium voltage-gated channel, shaker-related subfamily, member 4	voltage-gated potassium channel subunit Kv1.4

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07100	KCNA4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21608	Kcna4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS28126	Kcna4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcna4	NCBI	NCBI:3739

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