Gabrb2 - gamma-aminobutyric acid type A receptor subunit beta 2 Gene

Rattus norvegicus

Also known as GARB2

Gene ID: 25451 | Gene type: protein coding

About Gabrb2

Summary

Enables GABA-A receptor activity; Chloride Channel activity; and inhibitory extracellular ligand-gated ion channel activity. Contributes to GABA Receptor activity. Involved in GABAergic synaptic transmission; cellular response to histamine; and chloride transmembrane transport. Located in cytosol and membrane. Is integral component of plasma membrane. Part of GABA-A receptor complex. Human ortholog(s) of this gene implicated in autistic disorder and developmental and epileptic encephalopathy 92. Orthologous to human GABRB2 (gamma-aminobutyric acid type A receptor subunit beta2). [provided by Alliance of Genome Resources, Apr 2022]

Gabrb2 Products(1)

mRNA	Protein	Name
NM_012957.2	NP_037089.1	gamma-aminobutyric acid receptor subunit beta-2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to GABA receptor activity	IDA IDA: Inferred from direct assay	12930820	RGD
enables GABA-A receptor activity	IMP IMP: Inferred from mutant phenotype	11877425	RGD
enables chloride channel activity	IMP IMP: Inferred from mutant phenotype	18281286	RGD
enables inhibitory extracellular ligand-gated monoatomic ion channel activity	IMP IMP: Inferred from mutant phenotype	11877425	RGD
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA IDA: Inferred from direct assay	26592470	RGD
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	26592470	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11350968	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to histamine	IDA IDA: Inferred from direct assay	18281286	RGD
involved in chloride transmembrane transport	IMP IMP: Inferred from mutant phenotype	18281286	RGD
involved in synaptic transmission, GABAergic	IDA IDA: Inferred from direct assay	12930820	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of GABA receptor complex	IDA IDA: Inferred from direct assay	12930820	RGD
part of GABA-A receptor complex	IMP IMP: Inferred from mutant phenotype	18281286	RGD
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	15174078	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	15174078	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	9464994	RGD
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	18281286	RGD
is active in postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	15174078	RGD
located in postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	9464994	RGD
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	15174078	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

gamma-aminobutyric acid receptor subunit beta-2

GABA(A) receptor subunit beta-2	Gamma-aminobutyric acid receptor beta 2
gamma-aminobutyric acid (GABA) A receptor, beta 2	gamma-aminobutyric acid (GABA-A) receptor, subunit beta 2
gamma-aminobutyric acid type A receptor beta 2 subunit

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05216	GABRB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21133	Gabrb2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27651	Gabrb2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gabrb2	NCBI	NCBI:2561

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