Fnta - farnesyltransferase, CAAX box, alpha Gene

Rattus norvegicus

Also known as PFAS

Gene ID: 25318 | Gene type: protein coding

About Fnta

Summary

Contributes to several functions, including peptide binding activity; Protein Prenyltransferase activity; and zinc ion binding activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of cell population proliferation; and regulation of nitric-oxide synthase biosynthetic process. Located in cytoplasm. Part of CAAX-protein geranylgeranyltransferase complex. Orthologous to human FNTA (farnesyltransferase, CAAX box, alpha). [provided by Alliance of Genome Resources, Apr 2022]

Fnta Products(1)

mRNA	Protein	Name
NM_012847.2	NP_036979.2	protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to CAAX-protein geranylgeranyltransferase activity	IDA IDA: Inferred from direct assay	8089111	RGD
contributes to heterocyclic compound binding	IDA IDA: Inferred from direct assay	15248757	RGD
contributes to peptide binding	IDA IDA: Inferred from direct assay	9705207	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9065406	RGD
contributes to protein farnesyltransferase activity	IDA IDA: Inferred from direct assay	8089111	RGD
enables protein farnesyltransferase activity	IDA IDA: Inferred from direct assay	1763049	RGD
contributes to small molecule binding	IDA IDA: Inferred from direct assay	15248757	RGD
contributes to zinc ion binding	IDA IDA: Inferred from direct assay	15248757	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	11313965	RGD
involved in negative regulation of nitric-oxide synthase biosynthetic process	IMP IMP: Inferred from mutant phenotype	9153192	RGD
involved in positive regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	10544242	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	10544242	RGD
involved in positive regulation of nitric-oxide synthase biosynthetic process	IMP IMP: Inferred from mutant phenotype	9153192	RGD
involved in response to cytokine	IMP IMP: Inferred from mutant phenotype	9153192	RGD
involved in response to organic cyclic compound	IMP IMP: Inferred from mutant phenotype	16257390	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of CAAX-protein geranylgeranyltransferase complex	IDA IDA: Inferred from direct assay	15248757	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

CAAX farnesyltransferase subunit alpha	FTase-alpha
Farnesyltransferase, subunit alpha	GGTase-I-alpha
ras proteins prenyltransferase subunit alpha	type I protein geranyl-geranyltransferase subunit alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05025	FNTA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22173	Fnta Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28695	Fnta Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fnta	NCBI	NCBI:2339

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