Chrna7 - cholinergic receptor nicotinic alpha 7 subunit Gene

Rattus norvegicus

Also known as BTX; NARAD; nAChRa7

Gene ID: 25302 | Gene type: protein coding

About Chrna7

Summary

Enables several functions, including acetylcholine binding activity; acetylcholine-gated cation-selective channel activity; and enzyme binding activity. Involved in several processes, including dopamine biosynthetic process; neuronal action potential; and regulation of ERK1 and ERK2 cascade. Acts upstream of or within calcium ion transport and regulation of membrane potential. Located in several cellular components, including dendrite; plasma membrane raft; and postsynaptic density. Part of acetylcholine-gated channel complex. Is active in cholinergic synapse and glycinergic synapse. Is integral component of postsynaptic specialization membrane; integral component of presynaptic membrane; and integral component of spine apparatus membrane. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to several human genes including CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion). [provided by Alliance of Genome Resources, Apr 2022]

Chrna7 Products(1)

mRNA	Protein	Name
NM_012832.4	NP_036964.3	neuronal acetylcholine receptor subunit alpha-7 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase binding	IDA IDA: Inferred from direct assay	22593058	RGD
enables acetylcholine binding	IDA IDA: Inferred from direct assay	11297818	RGD
enables acetylcholine binding	IMP IMP: Inferred from mutant phenotype	16186249	RGD
enables acetylcholine-gated monoatomic cation-selective channel activity	IDA IDA: Inferred from direct assay	11222635	RGD
enables acetylcholine-gated monoatomic cation-selective channel activity	IMP IMP: Inferred from mutant phenotype	11259617	RGD
enables adenylate cyclase binding	IPI IPI: Inferred from physical interaction	12748066	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10627589	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	12244045	RGD
enables scaffold protein binding	IDA IDA: Inferred from direct assay	22593058	RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	EXP EXP: Inferred from Experiment	15044058	RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA IDA: Inferred from direct assay	15044058	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in acetylcholine receptor signaling pathway	IDA IDA: Inferred from direct assay	21540349	RGD
acts upstream of or within calcium ion transport	IMP IMP: Inferred from mutant phenotype	15760934	RGD
involved in dopamine biosynthetic process	IEP IEP: Inferred from expression pattern	12438507	RGD
involved in learning or memory	IMP IMP: Inferred from mutant phenotype	17055644	RGD
involved in memory	IDA IDA: Inferred from direct assay	17898229	RGD
involved in monoatomic ion transmembrane transport	IDA IDA: Inferred from direct assay	16282518	RGD
involved in negative regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	20505147	RGD
involved in neuronal action potential	IMP IMP: Inferred from mutant phenotype	15044058	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	17898229	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	11404397	RGD
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	17379406	RGD
involved in presynaptic modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	21762741	RGD
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	21762741	RGD
acts upstream of or within regulation of membrane potential	IDA IDA: Inferred from direct assay	11222635	RGD
acts upstream of or within regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	15760934	RGD
involved in regulation of response to drug	IDA IDA: Inferred from direct assay	16282518	RGD
involved in response to acetylcholine	IDA IDA: Inferred from direct assay	16282518	RGD
involved in response to carbamate	IEP IEP: Inferred from expression pattern	15179037	RGD
involved in response to nicotine	IDA IDA: Inferred from direct assay	15801858	RGD
involved in response to nicotine	IGI IGI: Inferred from genetic interaction	11404397	RGD
involved in sensory processing	IDA IDA: Inferred from direct assay	17898229	RGD
involved in synaptic transmission, cholinergic	IMP IMP: Inferred from mutant phenotype	15044058	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of acetylcholine-gated channel complex	IDA IDA: Inferred from direct assay	11259617	RGD
located in asymmetric synapse	IDA IDA: Inferred from direct assay	12077196	RGD
located in axon	IDA IDA: Inferred from direct assay	12077196	RGD
is active in cholinergic synapse	EXP EXP: Inferred from Experiment	15044058	RGD
is active in cholinergic synapse	IDA IDA: Inferred from direct assay	15044058	RGD
located in dendrite	IDA IDA: Inferred from direct assay	11297818	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	12077196	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	12077196	RGD
is active in glycinergic synapse	EXP EXP: Inferred from Experiment	21762741	RGD
is active in glycinergic synapse	IDA IDA: Inferred from direct assay	21762741	RGD
located in growth cone	IDA IDA: Inferred from direct assay	12645078	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	11297818	RGD
located in plasma membrane raft	IDA IDA: Inferred from direct assay	21540349	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	24607281	RGD
is active in postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	11588172	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	11588172	RGD
located in presynaptic membrane	IDA IDA: Inferred from direct assay	12077196	RGD
is active in spine apparatus membrane	IDA IDA: Inferred from direct assay	11588172	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neuronal acetylcholine receptor subunit alpha-7

C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha)	bungarotoxin alpha
cholinergic receptor, nicotinic, alpha 7 (neuronal)	cholinergic receptor, nicotinic, alpha polypeptide 7
n

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02672	CHRNA7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19768	Chrna7 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26265	Chrna7 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Chrna7	NCBI	NCBI:1139

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