Rgn - regucalcin Gene

Rattus norvegicus

Also known as Rc; GNL; Reguc

Gene ID: 25106 | Gene type: protein coding

About Rgn

Summary

Enables calcium ion binding activity and gluconolactonase activity. Involved in several processes, including negative regulation of nitrogen compound metabolic process; positive regulation of hydrolase activity; and positive regulation of lipid biosynthetic process. Located in cytosol and nucleus. Used to study familial hyperlipidemia. Biomarker of hepatocellular carcinoma. Orthologous to human RGN (regucalcin). [provided by Alliance of Genome Resources, Apr 2022]

Rgn Products(1)

mRNA	Protein	Name
NM_031546.2	NP_113734.1	regucalcin

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	699201	RGD
enables gluconolactonase activity	IDA IDA: Inferred from direct assay	16585534	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in intracellular calcium ion homeostasis	IDA IDA: Inferred from direct assay	16786169	RGD
involved in kidney development	IEP IEP: Inferred from expression pattern	8794449	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	8794449	RGD
involved in liver regeneration	IEP IEP: Inferred from expression pattern	7759556	RGD
involved in negative regulation of DNA biosynthetic process	IMP IMP: Inferred from mutant phenotype	11500948	RGD
involved in negative regulation of DNA catabolic process	IDA IDA: Inferred from direct assay	2001740	RGD
involved in negative regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	11510494	RGD
involved in negative regulation of RNA biosynthetic process	IMP IMP: Inferred from mutant phenotype	12397604	RGD
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	15806309	RGD
involved in negative regulation of bone development	IDA IDA: Inferred from direct assay	12239582	RGD
involved in negative regulation of bone development	IMP IMP: Inferred from mutant phenotype	11129957	RGD
involved in negative regulation of calcium-dependent ATPase activity	IMP IMP: Inferred from mutant phenotype	10861851	RGD
involved in negative regulation of cyclic-nucleotide phosphodiesterase activity	IDA IDA: Inferred from direct assay	1656206	RGD
involved in negative regulation of epithelial cell proliferation	IDA IDA: Inferred from direct assay	16142398	RGD
involved in negative regulation of flagellated sperm motility	IDA IDA: Inferred from direct assay	23615721	RGD
involved in negative regulation of macromolecule biosynthetic process	IDA IDA: Inferred from direct assay	2280766	RGD
involved in negative regulation of nitric oxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	12686401	RGD
involved in negative regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	11455566	RGD
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	9827702	RGD
involved in positive regulation of ATP-dependent activity	IDA IDA: Inferred from direct assay	16786169	RGD
involved in positive regulation of ATPase-coupled calcium transmembrane transporter activity	IDA IDA: Inferred from direct assay	10797571	RGD
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	11693188	RGD
involved in positive regulation of fatty acid biosynthetic process	IDA IDA: Inferred from direct assay	16817230	RGD
involved in positive regulation of glucose metabolic process	IDA IDA: Inferred from direct assay	16817230	RGD
involved in positive regulation of phosphatase activity	IMP IMP: Inferred from mutant phenotype	9671264	RGD
involved in positive regulation of proteolysis involved in protein catabolic process	IDA IDA: Inferred from direct assay	1513338	RGD
involved in positive regulation of superoxide dismutase activity	IDA IDA: Inferred from direct assay	15375603	RGD
involved in positive regulation of triglyceride biosynthetic process	IDA IDA: Inferred from direct assay	16817230	RGD
involved in regulation of calcium-mediated signaling	IDA IDA: Inferred from direct assay	16786169	RGD
involved in spermatogenesis	IDA IDA: Inferred from direct assay	23615721	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

regucalcin

SMP-30	gluconolactonase
regucalcin (senescence marker protein-30)	senescence marker protein 30

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-176305S	Neurofilament, U-15N		/	Unkown
HY-RS11896	RGN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19568	Rgn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26065	Rgn Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rgn	NCBI	NCBI:9104

Name
Email *

	Sorry, but the email address you supplied was invalid.