Nppb - natriuretic peptide B Gene

Rattus norvegicus

Also known as BNP; Bnf

Gene ID: 25105 | Gene type: protein coding

About Nppb

Summary

Enables hormone activity. Involved in several processes, including cellular response to mechanical stimulus; negative regulation of cell population proliferation; and positive regulation of cGMP-mediated signaling. Located in several cellular components, including extracellular space; perinuclear region of cytoplasm; and transport vesicle. Used to study hypertension; hypertensive heart disease; myocardial infarction; polycystic kidney disease; and proteinuria. Biomarker of several diseases, including artery disease (multiple); heart disease (multiple); hyperhomocysteinemia; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in atherosclerosis; hypertension; myocardial infarction; obesity; and systolic heart failure. Orthologous to human NPPB (natriuretic peptide B). [provided by Alliance of Genome Resources, Apr 2022]

Nppb Products(1)

mRNA	Protein	Name
NM_031545.1	NP_113733.1	natriuretic peptides B precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables hormone activity	IDA IDA: Inferred from direct assay	7552344	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell growth involved in cardiac muscle cell development	IEP IEP: Inferred from expression pattern	7657802	RGD
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	21812548	RGD
involved in heart development	IEP IEP: Inferred from expression pattern	8027030	RGD
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	17487460	RGD
involved in negative regulation of cholangiocyte proliferation	IDA IDA: Inferred from direct assay	28416225	RGD
involved in negative regulation of smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	19104909	RGD
involved in negative regulation of systemic arterial blood pressure	IDA IDA: Inferred from direct assay	8289999	RGD
involved in positive regulation of cGMP-mediated signaling	IDA IDA: Inferred from direct assay	7552344	RGD
involved in positive regulation of collecting lymphatic vessel constriction	IDA IDA: Inferred from direct assay	23897233	RGD
involved in positive regulation of urine volume	IDA IDA: Inferred from direct assay	8289999	RGD
involved in response to 3-methylcholanthrene	IEP IEP: Inferred from expression pattern	19889059	RGD
involved in response to calcium ion	IEP IEP: Inferred from expression pattern	17332063	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	17822384	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	22224641	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	33310031	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	17673002	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	17919123	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	17767048	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	17332063	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16270351	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

natriuretic peptides B

Brain natriuretic factor	brain natriuretic factor prohormone
brain natriuretic peptide	gamma-brain natriuretic peptide
iso-ANP	natriuretic peptide precursor B
natriuretic peptide precursor type B	preproBNP
proBNP

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101012	NPPB	Inhibitor	99.78%	Unkown
HY-153392	TYA-018	Inhibitor	99.84%	Unkown
HY-RS09495	NPPB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16787	Nppb Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23227	Nppb Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nppb	NCBI	NCBI:4879

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