Atp7a - ATPase copper transporting alpha Gene

Rattus norvegicus

Also known as Mnk

Gene ID: 24941 | Gene type: protein coding

About Atp7a

Summary

This gene encodes a transmembrane protein that functions in copper transport across membranes. The protein localizes to the trans-Golgi network, where it is predicted to supply copper to copper-dependent Enzymes in the secretory pathway. The protein relocalizes to the plasma membrane under conditions of elevated extracellular copper and functions in the efflux of copper from cells. In human, mutations in this gene result in Menkes disease, X-linked cutis laxa, and occipital horn syndrome. [provided by RefSeq, Nov 2009]

Atp7a Products(1)

mRNA	Protein	Name
NM_052803.2	NP_434690.1	copper-transporting ATPase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	23349186	RGD
enables small GTPase binding	IPI IPI: Inferred from physical interaction	20671235	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to amino acid stimulus	IMP IMP: Inferred from mutant phenotype	26722473	RGD
involved in cellular response to antibiotic	IEP IEP: Inferred from expression pattern	23814049	RGD
involved in cellular response to cadmium ion	IEP IEP: Inferred from expression pattern	17584760	RGD
involved in cellular response to cobalt ion	IEP IEP: Inferred from expression pattern	23814049	RGD
involved in cellular response to copper ion	IDA IDA: Inferred from direct assay	20671235	RGD
involved in cellular response to copper ion	IEP IEP: Inferred from expression pattern	23174565	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	21346155	RGD
involved in cellular response to iron ion	IEP IEP: Inferred from expression pattern	19679821	RGD
involved in cellular response to lead ion	IEP IEP: Inferred from expression pattern	24316150	RGD
involved in cellular response to platelet-derived growth factor stimulus	IMP IMP: Inferred from mutant phenotype	20671235	RGD
involved in copper ion export	IMP IMP: Inferred from mutant phenotype	22442359	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	28089327	RGD
involved in in utero embryonic development	IEP IEP: Inferred from expression pattern	10864443	RGD
involved in lactation	IEP IEP: Inferred from expression pattern	16741141	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	25349135	RGD
involved in negative regulation of iron ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	24174620	RGD
involved in positive regulation of cell size	IMP IMP: Inferred from mutant phenotype	26722473	RGD
involved in positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	25156967	RGD
involved in positive regulation of lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	20671235	RGD
involved in positive regulation of response to wounding	IMP IMP: Inferred from mutant phenotype	20671235	RGD
involved in positive regulation of vascular associated smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	20671235	RGD
involved in regulation of cytochrome-c oxidase activity	IMP IMP: Inferred from mutant phenotype	26722473	RGD
involved in response to copper ion	IDA IDA: Inferred from direct assay	17158254	RGD
involved in response to copper ion	IEP IEP: Inferred from expression pattern	15591161	RGD
involved in response to iron(III) ion	IEP IEP: Inferred from expression pattern	16629162	RGD
involved in response to lead ion	IEP IEP: Inferred from expression pattern	25579025	RGD
involved in response to manganese ion	IDA IDA: Inferred from direct assay	24614235	RGD
involved in response to manganese ion	IEP IEP: Inferred from expression pattern	24614235	RGD
involved in response to zinc ion	IEP IEP: Inferred from expression pattern	12840169	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	15634787	RGD
located in apical plasma membrane	IDA IDA: Inferred from direct assay	16081413	RGD
located in axon	IDA IDA: Inferred from direct assay	15634787	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	16081413	RGD
located in brush border membrane	IDA IDA: Inferred from direct assay	16081413	RGD
located in cell leading edge	IDA IDA: Inferred from direct assay	23349186	RGD
located in dendrite	IDA IDA: Inferred from direct assay	15634787	RGD
located in late endosome	IDA IDA: Inferred from direct assay	16741141	RGD
located in membrane	IDA IDA: Inferred from direct assay	12488345	RGD
located in microvillus	IDA IDA: Inferred from direct assay	24614235	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	20836889	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	17158254	RGD
located in secretory granule	IDA IDA: Inferred from direct assay	16185750	RGD
located in trans-Golgi network	IDA IDA: Inferred from direct assay	12488345	RGD
located in trans-Golgi network membrane	IDA IDA: Inferred from direct assay	15634787	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

copper-transporting ATPase 1

ATPase, Cu++ transporting, alpha polypeptide	copper pump 1
menkes disease-associated protein homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01235	ATP7A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17972	Atp7a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24443	Atp7a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atp7a	NCBI	NCBI:538

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