Stat5a - signal transducer and activator of transcription 5A Gene

Rattus norvegicus

Also known as Stat5

Gene ID: 24918 | Gene type: protein coding

About Stat5a

Summary

Enables DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including mammary gland development; receptor signaling pathway via JAK-STAT; and response to ethanol. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in cytoplasm and nucleus. Orthologous to human STAT5A (signal transducer and activator of transcription 5A). [provided by Alliance of Genome Resources, Apr 2022]

Stat5a Products(1)

mRNA	Protein	Name
NM_017064.2	NP_058760.2	signal transducer and activator of transcription 5A

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11064147	RGD
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	8584036	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10713133	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11064147	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell surface receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	11064147	RGD
acts upstream of or within cellular response to cytokine stimulus	IDA IDA: Inferred from direct assay	19414010	RGD
acts upstream of or within cellular response to organic cyclic compound	IDA IDA: Inferred from direct assay	19414010	RGD
involved in lactation	IEP IEP: Inferred from expression pattern	7519723	RGD
involved in mammary gland involution	IDA IDA: Inferred from direct assay	16227201	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	16946407	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	16946407	RGD
involved in transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11064147	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

signal transducer and activator of transcription 5A

mammary gland factor

signal transducer and activator of transcription 5

Related Agents

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148813	AK-2292		99.73%	Unkown
HY-136546	Stafia-1	Inhibitor	99.39%	Unkown
HY-19527	IST5-002		99.83%	Unkown
HY-112648	Stafib-2	Inhibitor	98.42%	Unkown
HY-115464	NC1153		/	Unkown
HY-170837	STAT5-IN-3	Inhibitor	/	Unkown
HY-RS13892	STAT5A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19077	Stat5a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25568	Stat5a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stat5a	NCBI	NCBI:6776

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