2. Gene
  3. Wt1 - WT1 transcription factor Gene

Wt1 - WT1 transcription factor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 24883 | Gene type: protein coding

About Wt1

Summary

This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It plays an essential role in the normal development of the urogenital system, and the human gene is mutated in a small subset of patients with Wilm's tumors. Authors of PMID:7926762 provide evidence that Wt1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Jul 2008]

Wt1 Products(1)

mRNA Protein Name
NM_031534.2 NP_113722.2 Wilms tumor protein homolog
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
8389468 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11071895 RGD
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
8389468 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
11071895 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

Wilms tumor protein homolog

Wilms tumor 1

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14872 Tideglusib Inhibitor 99.79% Yes
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-104036 IDH-305 Inhibitor 98.75% Phase 2
Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-122913 Borussertib Inhibitor 99.18% Unkown
HY-W143698 PDGFRα kinase inhibitor 2 Inhibitor 98.95% Unkown
HY-156829B PLGA-PEG-PLGA (hydrogel) (LA:GA 7:1) / Unkown
HY-156829E PLGA-PEG-PLGA (hydrogel) (LA:GA 7:1) (15% solution) / Unkown
HY-156829H PLGA-PEG-PLGA (hydrogel) (LA:GA 7:1) (20% solution) / Unkown
HY-RS15853 WT1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-120765 BRD2879 Inhibitor / Unkown
HY-RS17032 Wt1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23476 Wt1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wt1 NCBI NCBI:7490
Mus musculus Wt1 NCBI NCBI:22431