Tac1 - tachykinin, precursor 1 Gene

Rattus norvegicus

Also known as TAC; PPTA3; Ppt5fl; RATPPTA3

Gene ID: 24806 | Gene type: protein coding

About Tac1

Summary

Enables substance P receptor binding activity. Involved in several processes, including learning or memory; positive regulation of secretion; and positive regulation of synaptic transmission. Located in extracellular space and plasma membrane. Used to study central sleep apnea and pulmonary hypertension. Biomarker of colitis and respiratory syncytial virus infectious disease. Orthologous to human TAC1 (tachykinin precursor 1). [provided by Alliance of Genome Resources, Apr 2022]

Tac1 Products(4)

mRNA	Protein	Name
NM_001124768.1	NP_001118240.1	protachykinin-1 isoform b precursor
NM_001124769.1	NP_001118241.1	protachykinin-1 isoform c precursor
NM_001124770.1	NP_001118242.1	protachykinin-1 isoform d precursor
NM_012666.2	NP_036798.1	protachykinin-1 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables substance P receptor binding	IDA IDA: Inferred from direct assay	18634782	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in associative learning	IDA IDA: Inferred from direct assay	19071162	RGD
involved in long-term memory	IDA IDA: Inferred from direct assay	19071162	RGD
involved in negative regulation of heart rate	IDA IDA: Inferred from direct assay	2471579	RGD
involved in positive regulation of action potential	IDA IDA: Inferred from direct assay	18158108	RGD
involved in positive regulation of acute inflammatory response	IDA IDA: Inferred from direct assay	19222484	RGD
involved in positive regulation of corticosterone secretion	IDA IDA: Inferred from direct assay	8391371	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	18634782	RGD
involved in positive regulation of epithelial cell migration	IDA IDA: Inferred from direct assay	17435548	RGD
involved in positive regulation of lymphocyte proliferation	IMP IMP: Inferred from mutant phenotype	18621988	RGD
involved in positive regulation of ossification	IDA IDA: Inferred from direct assay	17204323	RGD
involved in positive regulation of stress fiber assembly	IDA IDA: Inferred from direct assay	17435548	RGD
involved in positive regulation of synaptic transmission, GABAergic	IDA IDA: Inferred from direct assay	19261870	RGD
involved in positive regulation of synaptic transmission, cholinergic	IDA IDA: Inferred from direct assay	17949415	RGD
involved in regulation of blood pressure	IDA IDA: Inferred from direct assay	18938661	RGD
involved in response to hormone	IMP IMP: Inferred from mutant phenotype	18195491	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	18337316	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	18337316	RGD
is active in neuronal dense core vesicle	IDA IDA: Inferred from direct assay	6167867	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protachykinin-1

PPT	Tachykinin (substance P, neurokinin A, neuropeptide K, neuropeptide gamma)
tachykinin 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14136	TAC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18639	Tac1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25124	Tac1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tac1	NCBI	NCBI:6863

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