Prkar2b - protein kinase cAMP-dependent type II regulatory subunit beta Gene

Rattus norvegicus

Also known as RATDNA

Gene ID: 24679 | Gene type: protein coding

About Prkar2b

Summary

Enables cAMP binding activity; cAMP-dependent protein kinase regulator activity; and protein domain specific binding activity. Involved in regulation of protein kinase activity; response to antipsychotic drug; and response to clozapine. Located in several cellular components, including membrane raft; neuronal cell body; and perinuclear region of cytoplasm. Part of cAMP-dependent protein kinase complex. Orthologous to human PRKAR2B (protein kinase cAMP-dependent type II regulatory subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

Prkar2b Products(1)

mRNA	Protein	Name
NM_001030020.1	NP_001025191.1	cAMP-dependent protein kinase type II-beta regulatory subunit

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cAMP binding	IDA IDA: Inferred from direct assay	11907174	RGD
enables cAMP-dependent protein kinase regulator activity	IDA IDA: Inferred from direct assay	11907174	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	17610895	RGD
enables protein domain specific binding	IDA IDA: Inferred from direct assay	16996504	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of protein kinase activity	IDA IDA: Inferred from direct assay	11907174	RGD
involved in response to antipsychotic drug	IEP IEP: Inferred from expression pattern	11907174	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of cAMP-dependent protein kinase complex	IDA IDA: Inferred from direct assay	11907174	RGD
located in dendrite	IDA IDA: Inferred from direct assay	10618500	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	10618500	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	18550536	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cAMP-dependent protein kinase type II-beta regulatory subunit

Type II beta regulatory subunit of cAMP-dependent protein kinase	protein kinase cAMP-dependent type 2 regulatory subunit beta
protein kinase, cAMP dependent regulatory, type II beta	protein kinase, cAMP-dependent, regulatory subunit type II beta

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11115	PRKAR2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22021	Prkar2b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28539	Prkar2b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkar2b	NCBI	NCBI:5577

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