PLA2G4A - Pla2g4a phospholipase A2 group IVA Gene

Rattus norvegicus

Also known as Pla2c; cPLA2; Pla2g4

Gene ID: 24653 | Gene type: protein coding

About PLA2G4A

Summary

Enables calcium-dependent Phospholipase A2 activity and Histone Acetyltransferase binding activity. Involved in several processes, including positive regulation of prostaglandin biosynthetic process; reproductive structure development; and surfactant homeostasis. Located in several cellular components, including cytosol; perinuclear region of cytoplasm; and zymogen granule. Used to study hyperglycemia. Biomarker of asthma; brain ischemia; papilloma; polycystic kidney disease; and transitional cell carcinoma. Orthologous to human PLA2G4A (Phospholipase A2 group IVA). [provided by Alliance of Genome Resources, Apr 2022]

PLA2G4A Products(1)

mRNA	Protein	Name
NM_133551.2	NP_598235.2	cytosolic phospholipase A2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium-dependent phospholipase A2 activity	IDA IDA: Inferred from direct assay	8148815	RGD
enables histone acetyltransferase binding	IPI IPI: Inferred from physical interaction	11416127	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in arachidonate metabolic process	IMP IMP: Inferred from mutant phenotype	16603549	RGD
involved in cellular response to homocysteine	IEP IEP: Inferred from expression pattern	31125437	RGD
involved in decidualization	IMP IMP: Inferred from mutant phenotype	10050766	RGD
involved in luteolysis	IEP IEP: Inferred from expression pattern	11444430	RGD
involved in ovulation from ovarian follicle	IMP IMP: Inferred from mutant phenotype	10189070	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15486059	RGD
involved in positive regulation of bone mineralization	IEP IEP: Inferred from expression pattern	10807497	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17060404	RGD
involved in positive regulation of fever generation	IEP IEP: Inferred from expression pattern	16933973	RGD
involved in positive regulation of prostaglandin biosynthetic process	IMP IMP: Inferred from mutant phenotype	16203828	RGD
involved in positive regulation of vesicle fusion	IMP IMP: Inferred from mutant phenotype	17148545	RGD
involved in response to calcium ion	IMP IMP: Inferred from mutant phenotype	16828086	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	10092307	RGD
involved in response to hormone	IEP IEP: Inferred from expression pattern	15368358	RGD
involved in response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	16864412	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	17093905	RGD
involved in response to methylmercury	IEP IEP: Inferred from expression pattern	15019302	RGD
involved in response to vitamin D	IEP IEP: Inferred from expression pattern	15225789	RGD
involved in surfactant homeostasis	IMP IMP: Inferred from mutant phenotype	10025671	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15486059	RGD
located in zymogen granule	IDA IDA: Inferred from direct assay	17148545	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cytosolic phospholipase A2

cytosolic phospholipase A2-like	phospholipase A2 cytosolic
phospholipase A2, group IVA (cytosolic, calcium-dependent)

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18540	KT109	Inhibitor	99.82%	Unkown

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10626	PLA2G4A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17434	Pla2g4a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23889	Pla2g4a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	PLA2G4A	NCBI	NCBI:5321

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