2. Gene
  3. PDE4B - Pde4b phosphodiesterase 4B Gene

PDE4B - Pde4b phosphodiesterase 4B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Pde4B1; Pde4B2; Pde4B3; Pde4B4; Pde4b5; PDE4/IVb; Pde4b_v1; Pde4b_v2; Pde4b_v3; Pde4b_v4

Gene ID: 24626 | Gene type: protein coding

About PDE4B

Summary

Enables 3',5'-cyclic-AMP phosphodiesterase activity. Involved in response to heat. Located in cytosol; nucleus; and perinuclear region of cytoplasm. Orthologous to human PDE4B (phosphodiesterase 4B). [provided by Alliance of Genome Resources, Apr 2022]

PDE4B Products(2)

mRNA Protein Name
NM_001398935.1 NP_001385864.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 1
NM_017031.3 NP_058727.3 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 2
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
12441002 RGD
Cellular Component GO Annotation Evidence Reference Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
15242814 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

3',5'-cyclic AMP phosphodiesterase

DPDE4

Phosphodiesterase 4B, cAMP-specific (dunce

phosphodiesterase 4B, cAMP specific

phosphodiesterase type 4B5

Related Agents

Clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Phase
HY-153192 Nerandomilast Inhibitor 99.93% Phase 3
HY-153192A Nerandomilast dihydrate Inhibitor 99.93% Phase 3
HY-16900 Rolipram Inhibitor 99.45% Phase 2
HY-10469 GSK256066 Inhibitor 98.69% Phase 2
HY-117960 Orismilast Inhibitor 99.37% Phase 2
HY-112831 Osoresnontrine Inhibitor 99.88% Phase 2
HY-70069 GSK256066 Trifluoroacetate Inhibitor 99.54% Phase 2
HY-144683 PF-07038124 Inhibitor / Phase 2
HY-106003 GSK356278 Inhibitor 99.82% Phase 1
Pre-clinical Phase
Bioactive Molecules (33)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-128358 MR-L2 Activator 98.63% Unkown
HY-122942 Moracin M 98.90% Unkown
HY-115687 PDE4B-IN-2 Inhibitor 99.21% Unkown
HY-119190 PF-06445974 Inhibitor 98.23% Unkown
HY-16900A (R)-(-)-Rolipram Inhibitor 99.89% Unkown
HY-103050 ML-030 Inhibitor 99.50% Unkown
HY-131707 LEO 39652 Inhibitor 99.51% Unkown
HY-100246 CI-1044 Inhibitor 98.02% Unkown
HY-139178 KVA-D-88 Inhibitor 99.81% Unkown
HY-117977 FCPR03 Inhibitor 99.82% Unkown
HY-147830 PDE4B-IN-3 Inhibitor 99.37% Unkown
HY-115913 PDE4-IN-6 Inhibitor / Unkown
HY-121162 Mesembrine Inhibitor / Unkown
HY-144683A PF-07038124 hydrochloride Inhibitor / Unkown
HY-144684 PDE4-IN-8 Inhibitor / Unkown
HY-146201 PDE4B/7A-IN-1 Antagonist / Unkown
HY-146202 PDE4B/7A-IN-2 / Unkown
HY-147950 PDE4-IN-10 Inhibitor / Unkown
HY-159654 PDE4-IN-19 Inhibitor / Unkown
HY-161851 MDL3 Inhibitor / Unkown
HY-162582 Z19153 Inhibitor / Unkown
HY-162583 PDE4-IN-17 Inhibitor / Unkown
HY-163604 PDE4B/D-IN-1 Inhibitor / Unkown
HY-163605 PDE4B/D-IN-2 Inhibitor / Unkown
HY-163606 PDE4B/D-IN-3 Inhibitor / Unkown
HY-168558 PDE4B/D-IN-4 Inhibitor / Unkown
HY-172365 P7–2302 Inhibitor / Unkown
HY-172776 Phosphodiesterase-IN-3 Inhibitor / Unkown
HY-172870 PDE4B-IN-4 Inhibitor / Unkown
HY-RS10223 PDE4B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-119799 UK-500001 Inhibitor / Unkown
HY-RS16654 Pde4b Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23089 Pde4b Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens PDE4B NCBI NCBI:5142