Lepr - leptin receptor Gene

Rattus norvegicus

Also known as Fa

Gene ID: 24536 | Gene type: protein coding

About Lepr

Summary

Enables peptide hormone binding activity and protein-hormone receptor activity. Involved in several processes, including gonad development; negative regulation of locomotor rhythm; and positive regulation of cell communication. Located in extracellular space and plasma membrane. Used to study several diseases, including chronic kidney disease; glucose metabolism disease (multiple); obesity; pancreatitis; and renal fibrosis. Biomarker of pre-eclampsia and short bowel syndrome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); non-alcoholic fatty liver disease (multiple); obesity; obstructive sleep apnea; and type 2 diabetes mellitus. Orthologous to human LEPR (Leptin receptor). [provided by Alliance of Genome Resources, Apr 2022]

Lepr Products(1)

mRNA	Protein	Name
NM_012596.2	NP_036728.2	leptin receptor precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables peptide hormone binding	IDA IDA: Inferred from direct assay	9070213	RGD
enables peptide hormone binding	IMP IMP: Inferred from mutant phenotype	17023527	RGD
enables protein-hormone receptor activity	IDA IDA: Inferred from direct assay	9070213	RGD
enables protein-hormone receptor activity	IMP IMP: Inferred from mutant phenotype	17023527	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	12393625	RGD
involved in cellular response to acetate	IEP IEP: Inferred from expression pattern	12928006	RGD
involved in cellular response to butyrate	IEP IEP: Inferred from expression pattern	12928006	RGD
involved in eating behavior	IMP IMP: Inferred from mutant phenotype	12824696	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	12297537	RGD
involved in leptin-mediated signaling pathway	IDA IDA: Inferred from direct assay	9070213	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	11159367	RGD
involved in negative regulation of eating behavior	IMP IMP: Inferred from mutant phenotype	16982424	RGD
involved in negative regulation of locomotor rhythm	IMP IMP: Inferred from mutant phenotype	16982424	RGD
involved in ovulation from ovarian follicle	IEP IEP: Inferred from expression pattern	12959975	RGD
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	9618284	RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IDA IDA: Inferred from direct assay	9751766	RGD
involved in response to dexamethasone	IEP IEP: Inferred from expression pattern	12297537	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	15059958	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	15284063	RGD
involved in response to leptin	IEP IEP: Inferred from expression pattern	18515494	RGD
involved in response to lipid	IEP IEP: Inferred from expression pattern	9751212	RGD
involved in response to nicotine	IEP IEP: Inferred from expression pattern	12576193	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	18755573	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	16037380	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

leptin receptor

LEP-R	Leptin receptor (fatty)
OB receptor	OB-R

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990631	Mibavademab	Inhibitor	99.90%	Phase 3

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07594	LEPR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17371	Lepr Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23825	Lepr Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lepr	NCBI	NCBI:3953
Mus musculus	Lepr	NCBI	NCBI:16847

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