Hmgcs2 - 3-hydroxy-3-methylglutaryl-CoA synthase 2 Gene

Rattus norvegicus

Also known as Hmgcs1; Mt3h3mg

Gene ID: 24450 | Gene type: protein coding

About Hmgcs2

Summary

Enables hydroxymethylglutaryl-CoA synthase activity. Involved in several processes, including animal organ development; cellular response to lipid; and response to peptide hormone. Located in mitochondrial matrix. Biomarker of extrahepatic cholestasis. Orthologous to human HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2). [provided by Alliance of Genome Resources, Apr 2022]

Hmgcs2 Products(1)

mRNA	Protein	Name
NM_173094.2	NP_775117.2	hydroxymethylglutaryl-CoA synthase, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables hydroxymethylglutaryl-CoA synthase activity	IDA IDA: Inferred from direct assay	1971108	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in adipose tissue development	IEP IEP: Inferred from expression pattern	10357839	RGD
involved in cellular response to amino acid stimulus	IEP IEP: Inferred from expression pattern	20508999	RGD
involved in cellular response to fatty acid	IEP IEP: Inferred from expression pattern	20508999	RGD
involved in cellular response to glucocorticoid stimulus	IEP IEP: Inferred from expression pattern	9798904	RGD
involved in cellular response to hormone stimulus	IEP IEP: Inferred from expression pattern	9025717	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	12027802	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	11578593	RGD
involved in cellular response to organic cyclic compound	IEP IEP: Inferred from expression pattern	7694571	RGD
involved in ketone body biosynthetic process	IEP IEP: Inferred from expression pattern	12399220	RGD
involved in kidney development	IEP IEP: Inferred from expression pattern	8099282	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	8620869	RGD
involved in lung development	IEP IEP: Inferred from expression pattern	7911291	RGD
involved in midgut development	IEP IEP: Inferred from expression pattern	8620869	RGD
involved in multicellular organismal response to stress	IEP IEP: Inferred from expression pattern	16962226	RGD
involved in response to bacterium	IEP IEP: Inferred from expression pattern	14686922	RGD
involved in response to cAMP	IEP IEP: Inferred from expression pattern	7902069	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	17964421	RGD
involved in response to fatty acid	IEP IEP: Inferred from expression pattern	10796071	RGD
involved in response to glucagon	IEP IEP: Inferred from expression pattern	1967579	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	9546617	RGD
involved in response to growth hormone	IEP IEP: Inferred from expression pattern	11551854	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	9143333	RGD
involved in response to linoleic acid	IEP IEP: Inferred from expression pattern	16216487	RGD
involved in response to metal ion	IEP IEP: Inferred from expression pattern	8100835	RGD
involved in response to monosaccharide	IEP IEP: Inferred from expression pattern	1967579	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	17103110	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	20137896	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	12027802	RGD
involved in response to prostaglandin F	IEP IEP: Inferred from expression pattern	11517196	RGD
involved in response to starvation	IEP IEP: Inferred from expression pattern	10357839	RGD
involved in response to temperature stimulus	IEP IEP: Inferred from expression pattern	10357839	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	10357839	RGD
involved in response to triglyceride	IEP IEP: Inferred from expression pattern	11551854	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	11323196	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	17971398	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

hydroxymethylglutaryl-CoA synthase, mitochondrial

3-hydroxy-3-methylglutary-Coenzyme A synthase 2	3-hydroxy-3-methylglutaryl coenzyme A synthase
3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)
HMG-CoA synthase	hydroxymethylgl

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06242	HMGCS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18424	Hmgcs2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24905	Hmgcs2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hmgcs2	NCBI	NCBI:3158

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