Gstm2 - glutathione S-transferase mu 2 Gene

Rattus norvegicus

Also known as GSTA4

Gene ID: 24424 | Gene type: protein coding

About Gstm2

Summary

Enables glutathione binding activity; glutathione transferase activity; and identical protein binding activity. Involved in several processes, including glutathione metabolic process; response to phenylpropanoid; and xenobiotic catabolic process. Located in cytosol and plasma membrane. Part of protein-containing complex. Biomarker of hypertension. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system Cancer (multiple); hematologic Cancer (multiple); and lung disease (multiple). Orthologous to several human genes including GSTM1 (Glutathione S-transferase mu 1). [provided by Alliance of Genome Resources, Apr 2022]

Gstm2 Products(1)

mRNA	Protein	Name
NM_177426.2	NP_803175.1	glutathione S-transferase Mu 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables glutathione binding	IDA IDA: Inferred from direct assay	17112229	RGD
enables glutathione transferase activity	IDA IDA: Inferred from direct assay	17112229	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	11015213	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in glutathione metabolic process	IMP IMP: Inferred from mutant phenotype	12027896	RGD
involved in response to catechin	IEP IEP: Inferred from expression pattern	10927022	RGD
involved in response to genistein	IEP IEP: Inferred from expression pattern	19451092	RGD
involved in response to metal ion	IEP IEP: Inferred from expression pattern	23470461	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	14646352	RGD
involved in xenobiotic catabolic process	IDA IDA: Inferred from direct assay	17112229	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	17112229	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	11015213	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glutathione S-transferase Mu 2

GST 4-4	GST Yb2
GSTM2-2	Glutathione-S-transferase, mu type 2 (Yb2)
glutathione S-transferase M2	glutathione S-transferase Yb-2
glutathione S-transferase Yb2 subunit

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-A0122	Plicamycin	Inhibitor	99.60%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gstm2	NCBI	NCBI:2946

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