Gstm1 - glutathione S-transferase mu 1 Gene

Rattus norvegicus

Also known as GSTA3

Gene ID: 24423 | Gene type: protein coding

About Gstm1

Summary

Enables several functions, including glutathione binding activity; glutathione transferase activity; and nickel cation binding activity. Involved in several processes, including response to ethanol; response to lead ion; and response to lithium ion. Located in cytosol and extracellular region. Part of protein-containing complex. Used to study cholestasis. Biomarker of hypertension and liver cirrhosis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system Cancer (multiple); hematologic Cancer (multiple); and lung disease (multiple). Orthologous to human GSTM1 (Glutathione S-transferase mu 1). [provided by Alliance of Genome Resources, Apr 2022]

Gstm1 Products(1)

mRNA	Protein	Name
NM_017014.2	NP_058710.2	glutathione S-transferase Mu 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables glutathione binding	IDA IDA: Inferred from direct assay	17112229	RGD
enables glutathione transferase activity	IDA IDA: Inferred from direct assay	10229687	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	11015213	RGD
enables nickel cation binding	IDA IDA: Inferred from direct assay	7831282	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	23741294	RGD
enables steroid binding	IPI IPI: Inferred from physical interaction	10229687	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in glutathione metabolic process	IDA IDA: Inferred from direct assay	10229687	RGD
involved in glutathione metabolic process	IMP IMP: Inferred from mutant phenotype	12027896	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	11040448	RGD
involved in response to axon injury	IEP IEP: Inferred from expression pattern	20298122	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	22545783	RGD
involved in response to lead ion	IEP IEP: Inferred from expression pattern	9750042	RGD
involved in response to metal ion	IEP IEP: Inferred from expression pattern	23470461	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	18754104	RGD
involved in xenobiotic catabolic process	IDA IDA: Inferred from direct assay	17112229	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	17112229	RGD
located in extracellular region	IDA IDA: Inferred from direct assay	10229687	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	11015213	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glutathione S-transferase Mu 1

GST 3-3	GST Yb1
GSTM1-1	glutathione S-transferase M1
glutathione S-transferase Yb-1 subunit	glutathione-S-transferase, mu type 1 (Yb1)

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112534	GSTO-IN-2	Inhibitor	≥98.0%	Unkown
HY-RS05879	GSTM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20418	Gstm1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26927	Gstm1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gstm1	NCBI	NCBI:2944

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