Cyp1a1 - cytochrome P450, family 1, subfamily a, polypeptide 1 Gene

Rattus norvegicus

Also known as AHH; AHRR; CP11; CYP1; Cyp45c; P1-450; P450-C; P450DX; Cypc45c; P-450MC

Gene ID: 24296 | Gene type: protein coding

About Cyp1a1

Summary

Enables several functions, including flavonoid 3'-monooxygenase activity; heat shock protein binding activity; and oxidoreductase activity, acting on diphenols and related substances as donors. Contributes to oxidoreductase activity. Involved in several processes, including 9-cis-retinoic acid biosynthetic process; hepatocyte differentiation; and xenobiotic metabolic process. Located in mitochondrial inner membrane. Biomarker of end stage renal disease; heart disease; pulmonary hypertension; and renal cell carcinoma. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); diabetes mellitus (multiple); gastrointestinal system Cancer (multiple); hematologic Cancer (multiple); and lung disease (multiple). Orthologous to human CYP1A1 (Cytochrome P450 family 1 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp1a1 Products(1)

mRNA	Protein	Name
NM_012540.3	NP_036672.3	cytochrome P450 1A1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Hsp70 protein binding	IDA IDA: Inferred from direct assay	19401463	RGD
enables Hsp90 protein binding	IDA IDA: Inferred from direct assay	19401463	RGD
enables catalytic activity	IDA IDA: Inferred from direct assay	10381141	RGD
enables demethylase activity	IDA IDA: Inferred from direct assay	10915793	RGD
enables enzyme binding	IDA IDA: Inferred from direct assay	10891369	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	10891369	RGD
enables flavonoid 3'-monooxygenase activity	IDA IDA: Inferred from direct assay	18057719	RGD
enables monooxygenase activity	IDA IDA: Inferred from direct assay	8765131	RGD
contributes to oxidoreductase activity	IDA IDA: Inferred from direct assay	10528997	RGD
enables oxidoreductase activity	IDA IDA: Inferred from direct assay	11339718	RGD
enables oxidoreductase activity, acting on diphenols and related substances as donors	IDA IDA: Inferred from direct assay	12054491	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9454608	RGD
enables steroid hydroxylase activity	IDA IDA: Inferred from direct assay	11370669	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in 9-cis-retinoic acid biosynthetic process	IDA IDA: Inferred from direct assay	8765131	RGD
involved in camera-type eye development	IEP IEP: Inferred from expression pattern	15967433	RGD
involved in cellular response to copper ion	IEP IEP: Inferred from expression pattern	24599699	RGD
involved in coumarin metabolic process	IDA IDA: Inferred from direct assay	11780761	RGD
involved in dibenzo-p-dioxin catabolic process	IDA IDA: Inferred from direct assay	15812643	RGD
involved in dibenzo-p-dioxin catabolic process	IMP IMP: Inferred from mutant phenotype	12914780	RGD
involved in dibenzo-p-dioxin metabolic process	IDA IDA: Inferred from direct assay	12464257	RGD
involved in digestive tract development	IEP IEP: Inferred from expression pattern	12162855	RGD
involved in flavonoid metabolic process	IDA IDA: Inferred from direct assay	18057719	RGD
involved in hepatocyte differentiation	IEP IEP: Inferred from expression pattern	17574236	RGD
involved in insecticide metabolic process	IDA IDA: Inferred from direct assay	16169030	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	12162855	RGD
involved in maternal process involved in parturition	IEP IEP: Inferred from expression pattern	16226747	RGD
involved in nitric oxide metabolic process	IEP IEP: Inferred from expression pattern	31489946	RGD
involved in porphyrin-containing compound metabolic process	IDA IDA: Inferred from direct assay	12907239	RGD
involved in positive regulation of G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	14742689	RGD
involved in response to 2,3,7,8-tetrachlorodibenzodioxine	IEP IEP: Inferred from expression pattern	19373505	RGD
involved in response to 3-methylcholanthrene	IEP IEP: Inferred from expression pattern	10772642	RGD
involved in response to Aroclor 1254	IEP IEP: Inferred from expression pattern	19373505	RGD
involved in response to arsenic-containing substance	IEP IEP: Inferred from expression pattern	10329507	RGD
involved in response to diphenyl ether	IEP IEP: Inferred from expression pattern	18978342	RGD
involved in response to food	IEP IEP: Inferred from expression pattern	15740081	RGD
involved in response to genistein	IEP IEP: Inferred from expression pattern	25011215	RGD
involved in response to herbicide	IEP IEP: Inferred from expression pattern	12907239	RGD
involved in response to hyperoxia	IEP IEP: Inferred from expression pattern	16497785	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	11589108	RGD
involved in response to immobilization stress	IEP IEP: Inferred from expression pattern	14726153	RGD
involved in response to iron(III) ion	IEP IEP: Inferred from expression pattern	15211619	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	18308837	RGD
involved in response to nematode	IEP IEP: Inferred from expression pattern	12621079	RGD
involved in response to vitamin A	IEP IEP: Inferred from expression pattern	10381141	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	18774282	RGD
involved in tissue remodeling	IEP IEP: Inferred from expression pattern	23887904	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	19401463	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cytochrome P450 1A1

CYPIA1	P450MT2
P450form6	aryl hydrocarbon hydroxylase
cytochrome P1-450	cytochrome P450 form 6
cytochrome P450 subfamily I (aromatic compound-inducible) member A1 (C6 form c) (C6 form c)	cytochrome P450, 1a1
cytochrome P450, subfamily I (aromatic

Related Agents

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0822	Fipronil		99.01%	Unkown
HY-B1234	Octinoxate		99.84%	Unkown
HY-W017113	2-Mercaptobenzothiazole	Activator	99.85%	Yes
HY-B0822R	Fipronil (Standard)		/	Unkown

Pre-clinical Phase

Bioactive Molecules (71)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-135829	BAY 2416964	Antagonist	99.59%	Unkown
HY-N0382	Galangin		99.96%	Unkown
HY-19340	TMS	Inhibitor	99.40%	Unkown
HY-N2194	Bergamottin	Inhibitor	99.80%	Unkown
HY-D0145	7-Ethoxyresorufin	Inhibitor	99.61%	Unkown
HY-134217	KYN-101	Inhibitor	98.17%	Unkown
HY-N0563	Alizarin		99.48%	Unkown
HY-112628	CAY10464	Antagonist	99.77%	Unkown
HY-Y0110	2-Naphthol		99.91%	Unkown
HY-N2625A	Harmalol hydrochloride		99.72%	Unkown
HY-N4205	Tetrahydropiperine	Inhibitor	99.41%	Unkown
HY-N1082	Visnagin		99.46%	Unkown
HY-W007700	8-Bromooctanoic acid		99.89%	Unkown
HY-124421	5F-203	Inducer	99.04%	Unkown
HY-D0932	Sudan IV		≥98.0%	Unkown
HY-B2015	Carbosulfan	Inhibitor	≥98.0%	Unkown
HY-101284	DMU2105	Inhibitor	99.54%	Unkown
HY-152118	CYP1B1-IN-4	Inhibitor	99.09%	Unkown
HY-101285	DMU2139	Inhibitor	≥98.0%	Unkown
HY-103223	Phortress	Inducer	99.25%	Unkown
HY-117102	ANI-7	Activator	98.13%	Unkown
HY-N6264	26-Deoxyactein	Inhibitor	99.76%	Unkown
HY-118474	GW 610	Activator	99.78%	Unkown
HY-146393	PROTAC CYP1B1 degrader-1	Inhibitor	98.09%	Unkown
HY-N8382	Chalepensin	Inhibitor	≥98.0%	Unkown
HY-RS03443	CYP1B1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-157942	CYP1B1-IN-7	Inhibitor	99.88%	Unkown
HY-159006	CYP1B1 ligand 3	Inhibitor	/	Unkown
HY-B0973	Dibenzothiophene	Inhibitor	99.88%	Unkown
HY-118216	Bitertanol		/	Unkown
HY-120377	CYP1A1 inhibitor 8a	Inhibitor	/	Unkown
HY-128920	Phortress free base	Inhibitor	/	Unkown
HY-14225	BMS-764459		/	Unkown
HY-148592	Antitumor agent-87	Inhibitor	/	Unkown
HY-148595	Antitumor agent-88	Inhibitor	/	Unkown
HY-150557	CYP1B1-IN-1	Inhibitor	/	Unkown
HY-150558	CYP1B1-IN-2	Inhibitor	/	Unkown
HY-152079	CYP1B1-IN-3	Inhibitor	/	Unkown
HY-152196	CYP1B1-IN-5	Inhibitor	/	Unkown
HY-158429	PROTAC CYP1B1 degrader-2	Degrader	/	Unkown
HY-158430	CYP1B1 ligand 2		/	Unkown
HY-161403	CYP1B1-IN-8	Inhibitor	/	Unkown
HY-162051	CYP1B1-IN-6	Inhibitor	/	Unkown
HY-B0822S1	Fipronil-13C6		/	Unkown
HY-B0973S	Dibenzothiophene-d8	Inhibitor	/	Unkown
HY-B2015S	Carbosulfan-d18	Inhibitor	/	Unkown
HY-E70468	Human CYP1A1,High-Reductase		/	Unkown
HY-E70472	Human CYP1A1,Low-Reductase		/	Unkown
HY-E70476	Human CYP1B1,Low-Reductase		/	Unkown
HY-N0382R	Galangin (Standard)		/	Unkown
HY-N0382S	Galangin-13C3		/	Unkown
HY-N10344	Glucoarabin	Activator	/	Unkown
HY-RS03441	CYP1A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W762015	1,2,3,6,7,8-Hexachlorodibenzofuran	Inducer	/	Unkown
HY-Y0110S	2-Naphthol-d8		/	Unkown
HY-101284A	(E/Z)-DMU2105	Inhibitor	/	Unkown
HY-126308	(E/Z)-DMU2139	Inhibitor	/	Unkown
HY-158431	(S,R,S)-AHPC-Me-8-bromooctanoic acid		/	Unkown
HY-B1234S	Octinoxate-13C,d3		/	Unkown
HY-D0145S	7-Ethoxyresorufin-d5	Inhibitor	/	Unkown
HY-D0932S	Sudan IV-d6		/	Unkown
HY-N0922	Methysticin	Activator	/	Unkown
HY-N2689	(R)-6',7'-Dihydroxybergamottin	Inhibitor	/	Unkown
HY-RS16737	Cyp1a1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16945	Cyp1b1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23174	Cyp1a1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23388	Cyp1b1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W472509	11-HETE	Activator	/	Unkown
HY-W517092	1,2,3,4,7,8,9-Heptachlorodibenzofuran		/	Unkown
HY-W775354	1,2,3,4,7,8-Hexachlorodibenzofuran		/	Unkown
HY-Y0110S1	2-Naphthol-d7		95.00%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cyp1a1	NCBI	NCBI:1543

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