Rbck1 - RanBP-type and C3HC4-type zinc finger containing 1 Gene

Mus musculus

Also known as UIP28; HOIL-1; HOIL-1L; Ubce7ip3

Gene ID: 24105 | Gene type: protein coding

About Rbck1

Summary

Predicted to enable several functions, including protein kinase C binding activity; protein sequestering activity; and ubiquitin binding activity. Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NIK/NF-kappaB signaling; and positive regulation of apoptotic process. Acts upstream of or within negative regulation of necroptotic process and positive regulation of extrinsic apoptotic signaling pathway. Predicted to be part of LUBAC complex. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in glycogen storage disease. Orthologous to human RBCK1 (RANBP2-type and C3HC4-type zinc finger containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Rbck1 Products(3)

mRNA	Protein	Name
NM_001083921.1	NP_001077390.1	ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform a
NM_001355282.1	NP_001342211.1	ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform b
NM_019705.3	NP_062679.2	ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20956555	MGI
enables ubiquitin ligase activator activity	IDA IDA: Inferred from direct assay	34755089	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of necroptotic process	IGI IGI: Inferred from genetic interaction	22089168	MGI
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19136968	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	19136968	MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	19136968	MGI
involved in positive regulation of non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	19136968	MGI
involved in protein polyubiquitination	IMP IMP: Inferred from mutant phenotype	34755089	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of LUBAC complex	IDA IDA: Inferred from direct assay	19136968	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ranBP-type and C3HC4-type zinc finger-containing protein 1

RING-type E3 ubiquitin transferase HOIL-1	heme-oxidized IRP2 ubiquitin ligase 1 homolog
novel zinc finger, C3HC4 type (RING finger) protein	ubcM4-interacting protein 28
ubiquitin-conjugating enzyme 7-interacting protein 3

Rbck1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Rbck1	Q9WUB0	Rnf31	Mus musculus	Q924T7	Anti Bait CoIP	21455180
Intra	Rbck1	Q9WUB0	Rnf31	Mus musculus	Q924T7	GMS	21455180
Intra	Rbck1	Q9WUB0	Rnf31	Mus musculus	Q924T7	GMS	23942237

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11722	RBCK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20479	Rbck1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26987	Rbck1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rbck1	NCBI	NCBI:10616

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