2. Gene
  3. Tlk2 - tousled-like kinase 2 (Arabidopsis) Gene

Tlk2 - tousled-like kinase 2 (Arabidopsis) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Tlk; PKUalpha; PKU-alpha; 4933403M19Rik

Gene ID: 24086 | Gene type: protein coding

About Tlk2

Summary

Predicted to enable ATP binding activity; identical protein binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including cellular response to gamma radiation; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and peptidyl-serine phosphorylation. Predicted to act upstream of or within several processes, including chromatin organization; phosphorylation; and spermatogenesis. Located in intermediate filament; nucleus; and perinuclear region of cytoplasm. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human TLK2 (tousled like kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Tlk2 Products(6)

mRNA Protein Name
NM_001112705.2 NP_001106176.1 serine/threonine-protein kinase tousled-like 2 isoform A
NM_001294329.1 NP_001281258.1 serine/threonine-protein kinase tousled-like 2 isoform C
NM_001294330.1 NP_001281259.1 serine/threonine-protein kinase tousled-like 2 isoform D
NM_001294331.1 NP_001281260.1 serine/threonine-protein kinase tousled-like 2 isoform B
NM_001294334.1 NP_001281263.1 serine/threonine-protein kinase tousled-like 2 isoform E
NM_001361996.1 NP_001348925.1 serine/threonine-protein kinase tousled-like 2 isoform F
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
27782176 MGI
Cellular Component GO Annotation Evidence Reference Source
located in intermediate filament IDA
IDA: Inferred from direct assay
10455159 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10455159 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
10455159 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein kinase tousled-like 2

protein kinase U-alpha

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-162426 UNC-CA2-103 Inhibitor 99.26% Unkown
HY-RS14571 TLK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18263 Tlk2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24742 Tlk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tlk2 NCBI NCBI:11011