Ythdc2 - YTH domain containing 2 Gene

Mus musculus

Also known as mYTHDC2; 3010002F02Rik

Gene ID: 240255 | Gene type: protein coding

About Ythdc2

Summary

Enables 3'-5' RNA helicase activity and N6-methyladenosine-containing RNA binding activity. Involved in germline cell cycle switching, mitotic to meiotic cell cycle; oocyte development; and spermatid development. Located in cytoplasm and ribonucleoprotein granule. Is expressed in germ cell of ovary; ovary; seminiferous tubule; spermatocyte; and testis. Orthologous to human YTHDC2 (YTH domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Ythdc2 Products(1)

mRNA	Protein	Name
NM_001163013.1	NP_001156485.1	3'-5' RNA helicase YTHDC2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3'-5' RNA helicase activity	IDA IDA: Inferred from direct assay	29360036	MGI
enables N6-methyladenosine-containing RNA reader activity	IDA IDA: Inferred from direct assay	28809393	MGI
enables RNA binding	IDA IDA: Inferred from direct assay	29087293	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	26742488	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in germline cell cycle switching, mitotic to meiotic cell cycle	IMP IMP: Inferred from mutant phenotype	29033321	MGI
involved in oocyte development	IMP IMP: Inferred from mutant phenotype	29033321	MGI
involved in spermatid development	IMP IMP: Inferred from mutant phenotype	29033321	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	28380054	MGI
located in ribonucleoprotein granule	IDA IDA: Inferred from direct assay	29087293	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

3'-5' RNA helicase YTHDC2

YTH domain-containing protein C2	keen to exit meiosis leaving testes under-populated protein
ketu	probable ATP-dependent RNA helicase YTHDC2

Ythdc2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83572	YTHDC2 Antibody (YA3317)	WB, IP	Human

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-168610	YTH-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ythdc2	NCBI	NCBI:64848

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