YTHDC2 Antibody (YA3317)

YTHDC2 Antibody (YA3317) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to YTHDC2.

YTHDC2 is a 3'-5' RNA helicase that plays a crucial role in the male and female germline by promoting the transition from mitotic to meiotic divisions in stem cells. It specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs, influencing RNA processing efficiency and stability. YTHDC2 ensures the successful progression of the meiotic program in the germline by regulating the levels of m6A-containing RNAs. It functions by binding and promoting the degradation of m6A-containing mRNAs, a process requiring its 3'-5' RNA helicase activity, with RNA degradation potentially mediated by the XRN1 exoribonuclease. YTHDC2 is essential for both spermatogenesis and oogenesis. by similar: promotes meiotic transition, recognizes m6A modification, regulates RNA stability, mediates degradation via XRN1.

B2RR83

Predicted band size: 161 kDa; Observed band size: 161 kDa

Affinity Purified

Non-conjugated

Unmodified

Epigenetics and Nuclear Signaling

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

WB: 1:500-1:1000; IP: 1:20

WB, IP

Liquid

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

Recombinant protein of mouse YTHDC2