2. Gene
  3. Rnf13 - ring finger protein 13 Gene

Rnf13 - ring finger protein 13 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Rzf; 2010001H16Rik

Gene ID: 24017 | Gene type: protein coding

About Rnf13

Summary

This gene encodes a member of the PA-TM-RING family of proteins that contain a protease associated (PA) domain and a RING finger domain separated by a transmembrane (TM) domain. The encoded protein is an E3 ubiquitin Ligase localized to the endosomal-lysosomal vesicles and inner nuclear membrane. Mice lacking the encoded protein have impaired learning abilities associated with a decreased synaptic vesicle density and dysregulated SNARE complex assembly. Alternative splicing of this gene results in multiple transcript variants. A pseudogene for this gene has been identified on the X chromosome. [provided by RefSeq, Jan 2015]

Rnf13 Products(5)

mRNA Protein Name
NM_001113413.3 NP_001106884.1 E3 ubiquitin-protein ligase RNF13 isoform a precursor
NM_001304454.2 NP_001291383.1 E3 ubiquitin-protein ligase RNF13 isoform c
NM_001304456.2 NP_001291385.1 E3 ubiquitin-protein ligase RNF13 isoform d
NM_001357080.1 NP_001344009.1 E3 ubiquitin-protein ligase RNF13 isoform a precursor
NM_011883.5 NP_036013.1 E3 ubiquitin-protein ligase RNF13 isoform b precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
19292867 MGI
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
19292867 MGI
Biological Process GO Annotation Evidence Reference Source
involved in protein autoubiquitination IDA
IDA: Inferred from direct assay
19292867 MGI
Cellular Component GO Annotation Evidence Reference Source
located in late endosome membrane IDA
IDA: Inferred from direct assay
19292867 MGI
located in lysosomal membrane IDA
IDA: Inferred from direct assay
19292867 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF13

RING-type E3 ubiquitin transferase RNF13

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12047 RNF13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22778 Rnf13 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29292 Rnf13 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rnf13 NCBI NCBI:11342