2. Gene
  3. Adamts12 - a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12 Gene

Adamts12 - a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ADAMTS-12

Gene ID: 239337 | Gene type: protein coding

About Adamts12

Summary

This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active protease. Mice lacking the encoded protein exhibit increased angiogenic response and tumor invasion in different models of angiogenesis and, severe inflammation and delayed recovery when subjected to experimental conditions that induce colitis, endotoxic sepsis and pancreatitis. [provided by RefSeq, Jul 2016]

Adamts12 Products(1)

mRNA Protein Name
NM_175501.3 NP_780710.2 A disintegrin and metalloproteinase with thrombospondin motifs 12 preproprotein
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in chondrocyte differentiation IGI
IGI: Inferred from genetic interaction
29618652 MGI
involved in collagen fibril organization IGI
IGI: Inferred from genetic interaction
29618652 MGI
involved in ossification IGI
IGI: Inferred from genetic interaction
29618652 MGI
involved in ossification involved in bone maturation IGI
IGI: Inferred from genetic interaction
29618652 MGI
involved in proteoglycan metabolic process IGI
IGI: Inferred from genetic interaction
29618652 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

A disintegrin and metalloproteinase with thrombospondin motifs 12

a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-162284 BAY-9835 Antagonist 99.46% Unkown
HY-RS00293 ADAMTS12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20662 Adamts12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27173 Adamts12 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adamts12 NCBI NCBI:81792