Adamts5 - a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) Gene

Mus musculus

Also known as ADMP-2; ASMP-2; ADAMTS1; ADAM-TS5; ADAMTS11; 9530092O11Rik

Gene ID: 23794 | Gene type: protein coding

About Adamts5

Summary

This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active, zinc-dependent aggrecanase enzyme. Mice lacking the encoded protein are protected from surgery-induced osteoarthritis and antigen-induced arthritis. [provided by RefSeq, May 2016]

Adamts5 Products(1)

mRNA	Protein	Name
NM_011782.2	NP_035912.2	A disintegrin and metalloproteinase with thrombospondin motifs 5 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables endopeptidase activity	IMP IMP: Inferred from mutant phenotype	23233679	MGI
enables extracellular matrix binding	IDA IDA: Inferred from direct assay	24220035	MGI
enables heparin binding	IDA IDA: Inferred from direct assay	24220035	MGI
enables metallopeptidase activity	IDA IDA: Inferred from direct assay	33719441	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in aortic valve morphogenesis	IMP IMP: Inferred from mutant phenotype	23531444	MGI
acts upstream of or within defense response to bacterium	IGI IGI: Inferred from genetic interaction	23684986	MGI
involved in endocardial cushion morphogenesis	IGI IGI: Inferred from genetic interaction	23531444	MGI
involved in extracellular matrix disassembly	IMP IMP: Inferred from mutant phenotype	23233679	MGI
involved in myoblast fusion	IMP IMP: Inferred from mutant phenotype	23233679	MGI
involved in negative regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	28702327	MGI
involved in pulmonary valve morphogenesis	IMP IMP: Inferred from mutant phenotype	23531444	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	24220035	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

A disintegrin and metalloproteinase with thrombospondin motifs 5

aggrecanase-2

implantin

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12270	T-5224	Inhibitor	99.59%	Phase 2
HY-137430	Aldumastat	Inhibitor	99.36%	Phase 2

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114996	ADAMTS-5 Inhibitor	Inhibitor	99.59%	Unkown
HY-145061	ADAMTS-5-IN-3	Inhibitor	98.89%	Unkown
HY-P10398	5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA		92.55%	Unkown
HY-135710	ADAMTS-5-IN-2	Inhibitor	98.73%	Unkown
HY-P5419A	WAAG-3R TFA		99.94%	Unkown
HY-P10468	5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2		/	Unkown
HY-RS00305	ADAMTS5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-160822	AGG-523	Inhibitor	/	Unkown
HY-RS18432	Adamts5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24913	Adamts5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adamts5	NCBI	NCBI:11096

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