Brip1 - BRCA1 interacting protein C-terminal helicase 1 Gene

Mus musculus

Also known as OF; FACJ; Bach1; Fancj; 3110009N10Rik; 8030460J03Rik

Gene ID: 237911 | Gene type: protein coding

About Brip1

Summary

This gene encodes a member of the DEAH subfamily of DEAD box helicases. A similar protein in humans is both a DNA-dependent ATPase and a 5-prime-to-3-prime DNA helicase, and plays a role in the repair of DNA double stranded breaks through interaction with the breast cancer-associated tumor suppressor BRCA1. [provided by RefSeq, Feb 2011]

Brip1 Products(1)

mRNA	Protein	Name
NM_178309.2	NP_840094.1	Fanconi anemia group J protein homolog

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within chiasma assembly	IMP IMP: Inferred from mutant phenotype	26490168	MGI
acts upstream of or within double-strand break repair involved in meiotic recombination	IMP IMP: Inferred from mutant phenotype	26490168	MGI
acts upstream of or within homologous chromosome pairing at meiosis	IMP IMP: Inferred from mutant phenotype	26490168	MGI
acts upstream of or within male gonad development	IMP IMP: Inferred from mutant phenotype	26490168	MGI
acts upstream of or within meiotic DNA double-strand break processing involved in reciprocal meiotic recombination	IMP IMP: Inferred from mutant phenotype	26490168	MGI
acts upstream of or within seminiferous tubule development	IMP IMP: Inferred from mutant phenotype	26490168	MGI
acts upstream of or within spermatid development	IMP IMP: Inferred from mutant phenotype	26490168	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	26490168	MGI
acts upstream of or within spermatogonial cell division	IMP IMP: Inferred from mutant phenotype	26490168	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

Fanconi anemia group J protein homolog

ATP-dependent RNA helicase BRIP1

BRCA1-associated C-terminal helicase 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01623	BRIP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20866	Brip1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27381	Brip1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Brip1	NCBI	NCBI:83990

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