Atad5 - ATPase family, AAA domain containing 5 Gene

Mus musculus

Also known as Gm17; FRAG1; C130052G03Rik

Gene ID: 237877 | Gene type: protein coding

About Atad5

Summary

Predicted to enable DNA binding activity and DNA clamp unloader activity. Involved in cell population proliferation; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; and nuclear DNA replication. Acts upstream of or within several processes, including intracellular signal transduction; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; and positive regulation of B cell activation. Located in nucleus. Is expressed in liver; metanephros; midbrain ventricular layer; renal cortex; and telencephalon ventricular layer. Orthologous to human ATAD5 (ATPase family AAA domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]

Atad5 Products(2)

mRNA	Protein	Name
NM_001029856.2	NP_001025027.1	ATPase family AAA domain-containing protein 5
NM_001029856.2	NP_001025027.1	ATPase family AAA domain-containing protein 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15983387	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within DNA damage response	IMP IMP: Inferred from mutant phenotype	15983387	MGI
involved in cell population proliferation	IMP IMP: Inferred from mutant phenotype	25404367	MGI
acts upstream of or within immunoglobulin production	IMP IMP: Inferred from mutant phenotype	25404367	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage	IGI IGI: Inferred from genetic interaction	15983387	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IGI IGI: Inferred from genetic interaction	15983387	MGI
acts upstream of isotype switching	IMP IMP: Inferred from mutant phenotype	25404367	MGI
acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IMP IMP: Inferred from mutant phenotype	15983387	MGI
involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP IMP: Inferred from mutant phenotype	15983387	MGI
involved in nuclear DNA replication	IMP IMP: Inferred from mutant phenotype	25404367	MGI
acts upstream of nucleic acid metabolic process	IMP IMP: Inferred from mutant phenotype	25404367	MGI
acts upstream of or within positive regulation of B cell proliferation	IMP IMP: Inferred from mutant phenotype	25404367	MGI
acts upstream of or within positive regulation of isotype switching to IgG isotypes	IMP IMP: Inferred from mutant phenotype	25404367	MGI
acts upstream of or within regulation of mitotic cell cycle phase transition	IMP IMP: Inferred from mutant phenotype	25404367	MGI
acts upstream of or within signal transduction in response to DNA damage	IMP IMP: Inferred from mutant phenotype	15983387	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	15983387	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ATPase family AAA domain-containing protein 5

chromosome fragility associated gene 1

chromosome fragility-associated gene 1 protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122198	ML367	Inhibitor	99.84%	Unkown
HY-P10326	Z-ATAD-FMK	Inhibitor	/	Unkown
HY-RS01123	ATAD5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18987	Atad5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25476	Atad5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atad5	NCBI	NCBI:79915

Name
Email *

	Sorry, but the email address you supplied was invalid.