2. Gene
  3. Ptprq - protein tyrosine phosphatase, receptor type, Q Gene

Ptprq - protein tyrosine phosphatase, receptor type, Q Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as R-PTP-Q

Gene ID: 237523 | Gene type: protein coding

About Ptprq

Summary

Predicted to enable protein tyrosine Phosphatase activity. Acts upstream of or within several processes, including detection of mechanical stimulus involved in sensory perception of sound; hematopoietic progenitor cell differentiation; and vestibular receptor cell morphogenesis. Located in stereocilium bundle. Is expressed in cochlea; crista ampullaris; inner ear vestibular component; macula of utricle; and saccule. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 73 and autosomal recessive nonsyndromic deafness 84A. Orthologous to human PTPRQ (protein tyrosine Phosphatase receptor type Q). [provided by Alliance of Genome Resources, Apr 2022]

Ptprq Products(2)

mRNA Protein Name
NM_001081432.2 NP_001074901.1 phosphatidylinositol phosphatase PTPRQ isoform 2 precursor
NM_001370987.1 NP_001357916.1 phosphatidylinositol phosphatase PTPRQ isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
37952086 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within detection of mechanical stimulus involved in sensory perception of sound IMP
IMP: Inferred from mutant phenotype
22357859 MGI
acts upstream of or within hematopoietic progenitor cell differentiation IMP
IMP: Inferred from mutant phenotype
24029230 MGI
acts upstream of or within inner ear morphogenesis IMP
IMP: Inferred from mutant phenotype
14534255 MGI
acts upstream of or within neuromuscular process controlling balance IMP
IMP: Inferred from mutant phenotype
22357859 MGI
acts upstream of or within vestibular receptor cell morphogenesis IMP
IMP: Inferred from mutant phenotype
22357859 MGI
Cellular Component GO Annotation Evidence Reference Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
24285636 MGI
located in stereocilium base IDA
IDA: Inferred from direct assay
24285636 MGI
located in stereocilium bundle IDA
IDA: Inferred from direct assay
22357859 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phosphatidylinositol phosphatase PTPRQ

phosphotidylinositol phosphatase PTPRQ

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11447 PTPRQ Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS22753 Ptprq Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptprq NCBI NCBI:374462