Dchs1 - dachsous cadherin related 1 Gene

Mus musculus

Also known as FIB1; CDH25; Gm165; PCDH16; 3110041P15Rik; C130033F22Rik

Gene ID: 233651 | Gene type: protein coding

About Dchs1

Summary

Predicted to enable Cadherin binding activity and calcium ion binding activity. Involved in several processes, including cell migration; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and hippo signaling. Acts upstream of or within several processes, including animal organ development; condensed mesenchymal cell proliferation; and post-anal tail morphogenesis. Located in apical part of cell. Is expressed in several structures, including alimentary system; central nervous system; heart; hemolymphoid system gland; and lung. Used to study mitral valve prolapse. Human ortholog(s) of this gene implicated in Van Maldergem syndrome 1 and mitral valve prolapse. Orthologous to human DCHS1 (dachsous cadherin-related 1). [provided by Alliance of Genome Resources, Apr 2022]

Dchs1 Products(1)

mRNA	Protein	Name
NM_001162943.1	NP_001156415.1	protocadherin-16 precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in anatomical structure morphogenesis	IMP IMP: Inferred from mutant phenotype	26258302	MGI
acts upstream of or within branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	21303848	MGI
acts upstream of or within cell migration	IMP IMP: Inferred from mutant phenotype	26258302	MGI
involved in cell migration	IMP IMP: Inferred from mutant phenotype	26258302	MGI
acts upstream of or within cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	26258302	MGI
involved in cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	26258302	MGI
acts upstream of or within cochlea development	IMP IMP: Inferred from mutant phenotype	21303848	MGI
acts upstream of or within condensed mesenchymal cell proliferation	IGI IGI: Inferred from genetic interaction	26116661	MGI
acts upstream of or within condensed mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	26116661	MGI
acts upstream of or within digestive tract development	IMP IMP: Inferred from mutant phenotype	21303848	MGI
acts upstream of or within heart morphogenesis	IMP IMP: Inferred from mutant phenotype	21303848	MGI
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IDA IDA: Inferred from direct assay	19506035	MGI
involved in hippo signaling	IMP IMP: Inferred from mutant phenotype	24056717	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	21303848	MGI
acts upstream of or within mitral valve morphogenesis	IMP IMP: Inferred from mutant phenotype	26258302	MGI
involved in mitral valve morphogenesis	IMP IMP: Inferred from mutant phenotype	26258302	MGI
acts upstream of or within nephron development	IGI IGI: Inferred from genetic interaction	26116661	MGI
acts upstream of or within neural tube development	IMP IMP: Inferred from mutant phenotype	21303848	MGI
involved in neurogenesis	IMP IMP: Inferred from mutant phenotype	24056717	MGI
acts upstream of or within ossification involved in bone maturation	IMP IMP: Inferred from mutant phenotype	21303848	MGI
acts upstream of or within pattern specification process	IMP IMP: Inferred from mutant phenotype	26258302	MGI
involved in pattern specification process	IMP IMP: Inferred from mutant phenotype	26258302	MGI
acts upstream of or within post-anal tail morphogenesis	IMP IMP: Inferred from mutant phenotype	21303848	MGI
acts upstream of or within protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	26258302	MGI
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	26258302	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical part of cell	IDA IDA: Inferred from direct assay	19506035	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protocadherin-16

dachsous 1	protein Dchs1
protein dachsous homolog 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03575	DCHS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20902	Dchs1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27419	Dchs1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dchs1	NCBI	NCBI:8642

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