Ffar3 - free fatty acid receptor 3 Gene

Mus musculus

Also known as Gm478; Gpr41

Gene ID: 233080 | Gene type: protein coding

About Ffar3

Summary

Enables G protein-coupled receptor activity. Involved in several processes, including positive regulation of acute inflammatory response to non-antigenic stimulus; positive regulation of cytokine production; and regulation of secretion by cell. Acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; positive regulation of action potential; and regulation of heart rate by chemical signal. Is active in membrane. Is expressed in cervical ganglion; peripheral nerve trunk; superior cervical ganglion; sympathetic ganglion; and sympathetic nerve trunk. Orthologous to several human genes including FFAR3 (Free Fatty Acid Receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Ffar3 Products(1)

mRNA	Protein	Name
NM_001033316.2	NP_001028488.1	free fatty acid receptor 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	19047060	MGI
enables G protein-coupled receptor activity	IGI IGI: Inferred from genetic interaction	25581519	MGI
enables G protein-coupled receptor activity	IMP IMP: Inferred from mutant phenotype	23665276	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	19047060	MGI
involved in G protein-coupled receptor signaling pathway	IGI IGI: Inferred from genetic interaction	25581519	MGI
involved in G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	23665276	MGI
acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21518883	MGI
involved in cellular response to fatty acid	IMP IMP: Inferred from mutant phenotype	14722361	MGI
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	22190648	MGI
involved in mucosal immune response	IMP IMP: Inferred from mutant phenotype	23665276	MGI
involved in negative regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	23401498	MGI
involved in negative regulation of insulin secretion	IGI IGI: Inferred from genetic interaction	25581519	MGI
involved in negative regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	26091414	MGI
acts upstream of neuronal action potential	IMP IMP: Inferred from mutant phenotype	21518883	MGI
involved in positive regulation of acute inflammatory response to non-antigenic stimulus	IMP IMP: Inferred from mutant phenotype	23665276	MGI
involved in positive regulation of chemokine production	IMP IMP: Inferred from mutant phenotype	23665276	MGI
involved in positive regulation of cytokine production involved in immune response	IMP IMP: Inferred from mutant phenotype	23665276	MGI
acts upstream of or within positive regulation of neuronal action potential	IMP IMP: Inferred from mutant phenotype	21518883	MGI
acts upstream of or within regulation of heart rate by chemical signal	IMP IMP: Inferred from mutant phenotype	21518883	MGI
involved in regulation of hormone biosynthetic process	IMP IMP: Inferred from mutant phenotype	14722361	MGI
involved in regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	24748202	MGI
involved in regulation of norepinephrine secretion	IMP IMP: Inferred from mutant phenotype	22673524	MGI
involved in regulation of peptide hormone secretion	IMP IMP: Inferred from mutant phenotype	22190648	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in membrane	IDA IDA: Inferred from direct assay	19047060	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

free fatty acid receptor 3

G-protein coupled receptor 41

putative G protein-coupled receptor GPR41

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-116522	AR420626		98.29%	Unkown
HY-114060	CFMB		99.95%	Unkown
HY-RS04876	FFAR3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-114060A	(R)-CFMB	Control	99.75%	Unkown
HY-RS17461	Ffar3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23919	Ffar3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ffar3	NCBI	NCBI:2865

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