A2m - alpha-2-macroglobulin Gene

Mus musculus

Also known as A2mp

Gene ID: 232345 | Gene type: protein coding

About A2m

Summary

Predicted to enable several functions, including cytokine binding activity; growth factor binding activity; and serine-type endopeptidase inhibitor activity. Acts upstream of or within stem cell differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; embryo mesenchyme; liver; meninges; and retina. Human ortholog(s) of this gene implicated in COVID-19; background diabetic retinopathy; multiple sclerosis; neurodegenerative disease (multiple); and obstructive lung disease. Orthologous to human A2M (alpha-2-macroglobulin). [provided by Alliance of Genome Resources, Apr 2022]

A2m Products(1)

mRNA	Protein	Name
NM_175628.3	NP_783327.2	alpha-2-macroglobulin-P precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17920016	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within stem cell differentiation	IDA IDA: Inferred from direct assay	19796622	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

alpha-2-macroglobulin-P

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00010	A2M Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18322	A2m Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24800	A2m Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	A2m	NCBI	NCBI:2

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