RFTN1 - raftlin, lipid raft linker 1 Gene

Homo sapiens

Also known as MIG2; PIG9; PIB10; RAFTLIN

Gene ID: 23180 | Gene type: protein coding

About RFTN1

Cytogenetic location: 3p24.3 Genomic coordinates (GRCh38): 3:16,315,845-16,513,699 (from NCBI)

This gene has 12 transcripts (splice variants), 291 orthologues and 1 paralogue. Broad expression in lymph node (RPKM 35.0), fat (RPKM 23.7) and 23 other tissues.

Summary

Enables double-stranded RNA binding activity. Involved in B cell receptor signaling pathway; membrane raft assembly; and positive regulation of growth rate. Acts upstream of or within dsRNA transport; response to exogenous dsRNA; and Toll-like Receptor 3 signaling pathway. Located in endosome; membrane raft; and plasma membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

RFTN1 Products(1)

mRNA	Protein	Name
NM_015150.2	NP_055965.1	raftlin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	21266579	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in B cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12805216	GOA
acts upstream of or within dsRNA transport	IMP IMP: Inferred from mutant phenotype	21266579	GOA
involved in membrane raft assembly	IMP IMP: Inferred from mutant phenotype	12805216	GOA
involved in positive regulation of growth rate	IMP IMP: Inferred from mutant phenotype	12805216	GOA
acts upstream of or within response to exogenous dsRNA	IMP IMP: Inferred from mutant phenotype	21266579	GOA
acts upstream of or within toll-like receptor 3 signaling pathway	IMP IMP: Inferred from mutant phenotype	21266579	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21266579	GOA
located in endosome	IDA IDA: Inferred from direct assay	21266579	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	12805216	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12805216	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	21266579	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RFTN1 Protein Structure

Raftlin

0
100
200
300
400
500
578 a.a.

Protein Preferred Names

Protein Names

raftlin

cell migration-inducing gene 2 protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11877	RFTN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RFTN1	VGNC	VGNC:109570
Canis familiaris	RFTN1	VGNC	VGNC:45500
Felis catus	RFTN1	VGNC	VGNC:64584
Rattus norvegicus	RFTN1	RGD	RGD:1563347
Mus musculus	RFTN1	MGD	MGI:1923688
Macaca mulatta	RFTN1	VGNC	VGNC:76867

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