2. Gene
  3. Ece1 - endothelin converting enzyme 1 Gene

Ece1 - endothelin converting enzyme 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ECE-1; ECE-1a; ECE-1b; ECE-1d; ECE-1c1

Gene ID: 230857 | Gene type: protein coding

About Ece1

Summary

Predicted to enable metalloendopeptidase activity; protein homodimerization activity; and zinc ion binding activity. Involved in axonogenesis; embryonic heart tube development; and gene expression. Acts upstream of or within pharyngeal system development. Predicted to be located in several cellular components, including cytoplasmic vesicle; external side of plasma membrane; and perinuclear region of cytoplasm. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; male reproductive gland or organ; respiratory system; and sensory organ. Used to study double outlet right ventricle. Human ortholog(s) of this gene implicated in Alzheimer's disease; congestive heart failure; coronary artery disease; essential hypertension; and hypertension. Orthologous to human ECE1 (endothelin converting enzyme 1). [provided by Alliance of Genome Resources, Apr 2022]

Ece1 Products(4)

mRNA Protein Name
NM_001369177.1 NP_001356106.1 endothelin-converting enzyme 1 isoform a
NM_001369178.1 NP_001356107.1 endothelin-converting enzyme 1 isoform b
NM_001369179.1 NP_001356108.1 endothelin-converting enzyme 1 isoform c
NM_199307.2 NP_955011.1 endothelin-converting enzyme 1 isoform c
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in axon guidance IMP
IMP: Inferred from mutant phenotype
30735130 MGI
involved in axonogenesis involved in innervation IMP
IMP: Inferred from mutant phenotype
30735130 MGI
involved in embryonic heart tube development IMP
IMP: Inferred from mutant phenotype
30735130 MGI
involved in gene expression IMP
IMP: Inferred from mutant phenotype
30735130 MGI
involved in neuron projection development IMP
IMP: Inferred from mutant phenotype
24875861 MGI
acts upstream of or within pharyngeal system development IMP
IMP: Inferred from mutant phenotype
12950083 MGI
involved in semaphorin-plexin signaling pathway involved in axon guidance IMP
IMP: Inferred from mutant phenotype
30735130 MGI
involved in sympathetic neuron axon guidance IMP
IMP: Inferred from mutant phenotype
30735130 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

endothelin-converting enzyme 1

endothelin-converting enzyme-1a

endothelin-converting enzyme-1b

endothelin-converting enzyme-1c1

endothelin-converting enzyme-1d

Related Agents

Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P3749 Mca-(ala7,lys(dnp)9)-bradykinin 99.92% Unkown
HY-N11772 Mutanocyclin Inhibitor 99.94% Unkown
HY-107762 CGS35066 Inhibitor / Unkown
HY-119545 PD159790 Inhibitor / Unkown
HY-RS04133 ECE1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-18211 CGS 35601 Inhibitor / Unkown
HY-RS18611 Ece1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25097 Ece1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ece1 NCBI NCBI:1889