2. Gene
  3. Kdm4a - lysine (K)-specific demethylase 4A Gene

Kdm4a - lysine (K)-specific demethylase 4A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Jmjd2; JHDM3A; Jmjd2a; mKIAA0677; D4Ertd222e

Gene ID: 230674 | Gene type: protein coding

About Kdm4a

Summary

Enables Histone Demethylase activity. Acts upstream of or within cardiac muscle hypertrophy in response to stress and negative regulation of histone H3-K9 trimethylation. Located in pericentric heterochromatin. Is expressed in several structures, including branchial arch; central nervous system; dorsal root ganglion; early conceptus; and genitourinary system. Orthologous to human KDM4A (lysine demethylase 4A). [provided by Alliance of Genome Resources, Apr 2022]

Kdm4a Products(2)

mRNA Protein Name
NM_001161823.1 NP_001155295.1 lysine-specific demethylase 4A isoform 1
NM_172382.2 NP_759014.2 lysine-specific demethylase 4A isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables histone H3K9 demethylase activity IDA
IDA: Inferred from direct assay
16738407 MGI
enables histone demethylase activity IDA
IDA: Inferred from direct assay
19144645 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cardiac muscle hypertrophy in response to stress IMP
IMP: Inferred from mutant phenotype
21555854 MGI
Cellular Component GO Annotation Evidence Reference Source
located in pericentric heterochromatin IDA
IDA: Inferred from direct assay
16738407 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lysine-specific demethylase 4A

[histone H3]-trimethyl-L-lysine(36) demethylase 4A

[histone H3]-trimethyl-L-lysine(9) demethylase 4A

jmjC domain-containing histone demethylation protein 3A

jumonji domain containing 2A

jumonji domain-containing protein 2A

Related Agents

Pre-clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-104048 QC6352 Inhibitor 99.13% Unkown
HY-100760 Toxoflavin Inhibitor 99.88% Unkown
HY-107573 KDM2/7-IN-1 Inhibitor 99.00% Unkown
HY-110154 NSC636819 98.90% Unkown
HY-128343 KDM4-IN-2 Inhibitor 98.29% Unkown
HY-RS07213 KDM4A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-100760S Toxoflavin-13C4 Inhibitor / Unkown
HY-150619 KDM4-IN-4 Inhibitor / Unkown
HY-173135 PROTAC KDM4 degrader-1 / Unkown
HY-RS17467 Kdm4a Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23925 Kdm4a Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kdm4a NCBI NCBI:9682