Gtf2b - general transcription factor IIB Gene

Mus musculus

Gene ID: 229906 | Gene type: protein coding

About Gtf2b

Summary

Enables DNA binding activity and promoter-specific chromatin binding activity. Predicted to be involved in several processes, including RNA polymerase II core complex assembly; positive regulation of core promoter binding activity; and transcription initiation from RNA polymerase II promoter. Located in nucleus. Is expressed in cerebral cortex; pancreas; and testis. Orthologous to human GTF2B (general transcription factor IIB). [provided by Alliance of Genome Resources, Apr 2022]

Gtf2b Products(1)

mRNA	Protein	Name
NM_145546.1	NP_663521.1	transcription initiation factor IIB

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	18722179	MGI
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	22323595	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14612417	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromosome organization	IMP IMP: Inferred from mutant phenotype	24244602	MGI
involved in embryo development	IMP IMP: Inferred from mutant phenotype	24244602	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	24244602	MGI
involved in meiotic sister chromatid cohesion	IMP IMP: Inferred from mutant phenotype	24244602	MGI
involved in spindle assembly	IMP IMP: Inferred from mutant phenotype	24244602	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cell division site	IDA IDA: Inferred from direct assay	24244602	MGI
is active in condensed chromosome	IDA IDA: Inferred from direct assay	24244602	MGI
is active in germinal vesicle	IDA IDA: Inferred from direct assay	24244602	MGI
is active in kinetochore	IDA IDA: Inferred from direct assay	24244602	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	24244602	MGI
located in nucleus	IDA IDA: Inferred from direct assay	18722179	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription initiation factor IIB

RNA polymerase II alpha initiation factor

general transcription factor TFIIB

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05894	GTF2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21590	Gtf2b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28108	Gtf2b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gtf2b	NCBI	NCBI:2959

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