Ciart - circadian associated repressor of transcription Gene

Mus musculus

Also known as Gm129; Chrono

Gene ID: 229599 | Gene type: protein coding

About Ciart

Summary

Enables E-box binding activity. Involved in circadian regulation of gene expression; locomotor rhythm; and negative regulation of transcription, DNA-templated. Located in nucleus. Orthologous to human CIART (circadian associated repressor of transcription). [provided by Alliance of Genome Resources, Apr 2022]

Ciart Products(13)

mRNA	Protein	Name
NM_001033302.3	NP_001028474.1	circadian-associated transcriptional repressor isoform 1
NM_001411319.1	NP_001398248.1	circadian-associated transcriptional repressor isoform 1
NM_001411320.1	NP_001398249.1	circadian-associated transcriptional repressor isoform 1
NM_001411321.1	NP_001398250.1	circadian-associated transcriptional repressor isoform 1
NM_001411322.1	NP_001398251.1	circadian-associated transcriptional repressor isoform 1
NM_001411323.1	NP_001398252.1	circadian-associated transcriptional repressor isoform 1
NM_001411324.1	NP_001398253.1	circadian-associated transcriptional repressor isoform 2
NM_001411325.1	NP_001398254.1	circadian-associated transcriptional repressor isoform 2
NM_001411326.1	NP_001398255.1	circadian-associated transcriptional repressor isoform 2
NM_001411327.1	NP_001398256.1	circadian-associated transcriptional repressor isoform 2
NM_001411328.1	NP_001398257.1	circadian-associated transcriptional repressor isoform 2
NM_001411329.1	NP_001398258.1	circadian-associated transcriptional repressor isoform 3
NM_001411330.1	NP_001398259.1	circadian-associated transcriptional repressor isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables E-box binding	IDA IDA: Inferred from direct assay	24736997	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	24385426	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	24385426	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in circadian regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24385426	MGI
involved in locomotor rhythm	IMP IMP: Inferred from mutant phenotype	24736997	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	24385426	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	24385426	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

circadian-associated transcriptional repressor

chIP-derived repressor of network oscillator

computationally highlighted repressor of the network oscillator

Ciart Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Ciart	Q3TQ03	Cry2	Mus musculus	Q9R194	Anti Tag CoIP	24736997
Intra	Ciart	Q3TQ03	Per2	Mus musculus	O54943	Anti Tag CoIP	24736997
Intra	Ciart	Q3TQ03	Hdac1	Mus musculus	O09106	Anti Tag CoIP	24736997
Intra	Ciart	Q3TQ03	Bhlhe41	Mus musculus	Q99PV5	Anti Tag CoIP	24736997
Intra	Ciart	Q3TQ03	Bmal1	Mus musculus	Q9WTL8	Anti Tag CoIP	24736997
Intra	Ciart	Q3TQ03	Bmal1	Mus musculus	Q9WTL8	Anti Bait CoIP	24736997

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02705	CIART Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21529	Ciart Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28047	Ciart Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ciart	NCBI	NCBI:148523

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