Lrp4 - low density lipoprotein receptor-related protein 4 Gene

Mus musculus

Also known as mdig; Megf7; D230026E03; 6430526J12Rik

Gene ID: 228357 | Gene type: protein coding

About Lrp4

Summary

Enables protein homodimerization activity and receptor tyrosine kinase binding activity. Involved in several processes, including positive regulation of presynaptic membrane organization; positive regulation of skeletal muscle acetylcholine-gated channel clustering; and synapse organization. Acts upstream of or within several processes, including animal organ development; embryonic digit morphogenesis; and regionalization. Located in neuromuscular junction and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; eye; and genitourinary system. Used to study sclerosteosis 2. Human ortholog(s) of this gene implicated in Cenani-Lenz syndactyly syndrome; congenital myasthenic syndrome 17; and sclerosteosis 2. Orthologous to human LRP4 (LDL receptor related protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Lrp4 Products(2)

mRNA	Protein	Name
NM_001145857.1	NP_001139329.1	low-density lipoprotein receptor-related protein 4 isoform 2 precursor
NM_172668.3	NP_766256.3	low-density lipoprotein receptor-related protein 4 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables coreceptor activity	IDA IDA: Inferred from direct assay	18848351	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18848351	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	18848351	MGI
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	18848351	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Wnt signaling pathway	IDA IDA: Inferred from direct assay	16207730	MGI
acts upstream of or within anatomical structure development	IMP IMP: Inferred from mutant phenotype	17119023	MGI
acts upstream of or within dorsal/ventral pattern formation	IMP IMP: Inferred from mutant phenotype	16207730	MGI
acts upstream of or within embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	16517118	MGI
acts upstream of or within embryonic limb morphogenesis	IMP IMP: Inferred from mutant phenotype	16207730	MGI
involved in enzyme-linked receptor protein signaling pathway	IDA IDA: Inferred from direct assay	18848351	MGI
involved in enzyme-linked receptor protein signaling pathway	IGI IGI: Inferred from genetic interaction	8653787	MGI
involved in enzyme-linked receptor protein signaling pathway	IMP IMP: Inferred from mutant phenotype	14622576	MGI
acts upstream of or within hair follicle development	IMP IMP: Inferred from mutant phenotype	17119023	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	17119023	MGI
involved in negative regulation of axonogenesis	IMP IMP: Inferred from mutant phenotype	22854782	MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	20383322	MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	20383322	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IMP IMP: Inferred from mutant phenotype	17119023	MGI
involved in positive regulation of Rac protein signal transduction	IDA IDA: Inferred from direct assay	18848351	MGI
involved in positive regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	18957220	MGI
involved in positive regulation of presynaptic membrane organization	IDA IDA: Inferred from direct assay	22854782	MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering	IDA IDA: Inferred from direct assay	18848351	MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering	IGI IGI: Inferred from genetic interaction	8653787	MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering	IMP IMP: Inferred from mutant phenotype	14622576	MGI
involved in postsynaptic membrane assembly	IMP IMP: Inferred from mutant phenotype	22038977	MGI
involved in presynaptic membrane assembly	IMP IMP: Inferred from mutant phenotype	22038977	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	17119023	MGI
acts upstream of or within proximal/distal pattern formation	IMP IMP: Inferred from mutant phenotype	17119023	MGI
acts upstream of or within receptor clustering	IMP IMP: Inferred from mutant phenotype	17119023	MGI
involved in regulation of postsynapse assembly	IDA IDA: Inferred from direct assay	25407677	MGI
involved in regulation of postsynapse assembly	IMP IMP: Inferred from mutant phenotype	25407677	MGI
involved in regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	18848351	MGI
involved in skeletal muscle acetylcholine-gated channel clustering	IMP IMP: Inferred from mutant phenotype	22038977	MGI
involved in synaptic assembly at neuromuscular junction	IDA IDA: Inferred from direct assay	18957220	MGI
acts upstream of or within synaptic assembly at neuromuscular junction	IMP IMP: Inferred from mutant phenotype	17119023	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in neuromuscular junction	IDA IDA: Inferred from direct assay	18957220	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16263759	MGI
is active in synapse	IDA IDA: Inferred from direct assay	25407677	MGI
is active in synapse	IEP IEP: Inferred from expression pattern	25407677	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

low-density lipoprotein receptor-related protein 4

LDLR dan

LRP-4

Lrp4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86948	LRP4 Antibody (YA6641)	WB	Mouse, Rat

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03047	CORIN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07799	LRP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17975	Corin Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19911	Lrp4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26412	Lrp4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lrp4	NCBI	NCBI:4038

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